CAJ | 학술논문

妊娠期肝内胆汁淤积症(ICP)是中、晚孕期常见的特发性肝脏功能紊乱性疾病。该病以皮肤瘙痒及血清总胆汁酸(TBA)水平升高为典型临床特征。我国部分地区的 ICP 发病率远高于欧美国家。ICP 孕妇一般预后良好，但 ICP 对围生儿常危害严重，可引起早产、胎儿宫内窘迫、新生儿窒息、羊水胎粪污染甚至胎死宫内等。目前，多数学者认为围生儿不良结局与孕妇血清 TBA 水平有密切关系，但 ICP 导致不同妊娠结局的病理机制尚未完全阐明。笔者现从血清 TBA 异常升高对母儿影响的角度，对 ICP 与围生儿结局关系的研究进展进行综述。
임신기간내담즙어적증(ICP)시중、만잉기상견적특발성간장공능문란성질병。해병이피부소양급혈청총담즙산(TBA)수평승고위전형림상특정。아국부분지구적 ICP 발병솔원고우구미국가。ICP 잉부일반예후량호，단 ICP 대위생인상위해엄중，가인기조산、태인궁내군박、신생인질식、양수태분오염심지태사궁내등。목전，다수학자인위위생인불량결국여잉부혈청 TBA 수평유밀절관계，단 ICP 도치불동임신결국적병리궤제상미완전천명。필자현종혈청 TBA 이상승고대모인영향적각도，대 ICP 여위생인결국관계적연구진전진행종술。
Intrahepatic cholestasis of pregnancy (ICP)is a pregnancy-specific liver disease mainly during the third trimester.It could be characterized by maternal pruritus and raised serum total bile acids (TBA).The ICP incidences in some areas of China are much higher than that of Europe and North America.The pregnant women with ICP usually have good prognosis.But for perinatal infants,ICP is a potential harm,it can course preterm delivery,fetal distress,neonatal asphyxia,meconium-stained amniotic fluid and stillbirth and so on.At present,most scholars believe that the high level of serum TBA in pregnant woman with ICP have strong relationship with adverse perinatal outcomes,but the mechanism has not been fully elucidated. In this paper, the relationships between ICP and perinatal outcomes are summarized.