CAJ | 학술논문

文章亮点： 　　1此问题已知的信息：理想的神经材料应由3部分构成：支架、种子细胞和相关活性因子，其中支架是再造微环境的主要结构，也是搭载种子细胞或相关活性因子的实体，是当前研究的热点。 　　2文章增加的新信息：在临床研究方面，胶原蛋白基的神经修复支架材料已开始进入临床研究阶段。 　　3临床应用的意义：随着组织工程学的发展，用于支持和引导缺损部位神经再生的修复材料应运而生，在动物实验中取得了可喜的效果。
문장량점： 　　1차문제이지적신식：이상적신경재료응유3부분구성：지가、충자세포화상관활성인자，기중지가시재조미배경적주요결구，야시탑재충자세포혹상관활성인자적실체，시당전연구적열점。 　　2문장증가적신신식：재림상연구방면，효원단백기적신경수복지가재료이개시진입림상연구계단。 　　3림상응용적의의：수착조직공정학적발전，용우지지화인도결손부위신경재생적수복재료응운이생，재동물실험중취득료가희적효과。
BACKGROUND:Tissue engineering scaffolds can create proper nerve regeneration microenvironment, enrich nutritional factors for nerve regeneration and promote axonal growth. OBJECTIVE:To review the progress of tissue engineering scaffolds in nerve repair in recent years. METHODS:A computer-based retrieval was performed to search ful-text articles addressing tissue engineering scaffolds used to repair nerve damage published from 2009 to 2014 in PubMed databases using the keywords of “nerve regeneration, prostheses and implants” as wel as articles published from 2004 to 2014 in CNKI database using the keywords of “nerve repair, material” in Chinese. RESULTS AND CONCLUSION: Currently, scaffold materials for nerve damage mainly include natural materials, naturaly derived materials, synthetic materials and composites, al of which have their own advantages and disadvantages. By chemical crosslinkers or chemical modification, the naturaly derived polymer can be combined with other natural or synthetic composite materials, to improve their physicochemical and biological properties, i.e., the composite scaffolds have better effects than single materials in nerve regeneration. Therefore the current research focus is composite materials. In clinical research, colagen scaffold for nerve repair has entered the clinical research stage.