CAJ | 학술논문

目的：观察适度水解乳清蛋白配方奶对高变态反应风险儿童发生变态反应性疾病的预防作用,及其对儿童体格生长发育的影响。方法选取2012年10月至2013年10月于德阳市人民医院产科出生及参加儿童保健门诊的具有高变态反应风险的184例儿童为研究对象,采用随机数字表法将其分为干预组(n=91)和非干预组(n=93)。干预组儿童接受纯母乳喂养+适度水解乳清蛋白配方奶的饮食干预,非干预组儿童未接受特殊饮食干预。本研究遵循的程序符合德阳市人民医院人体试验委员会所制定的伦理学标准,得到该委员会批准,分组征得受试对象监护人的知情同意,并与之签署临床研究知情同意书。观察两组儿童变态反应性湿疹的发生情况,比较两组儿童在不同随访时间点的体格生长发育状况。结果两组患儿一般情况比较,差异均无统计学意义(P >0.05)。随访6,12个月时,干预组儿童变态反应性湿疹发生率和严重程度均小于非干预组(P <0.05)。随访3,6,9,12个月时,两组儿童体质量、身长、体质指数(BMI)比较,差异均无统计学意义(P >0.05)。结论采用母乳喂养+适度水解乳清蛋白配方奶的饮食干预能降低高变态反应风险儿童的变态反应性湿疹发生率及其严重程度,对其体格生长发育无影响。
목적：관찰괄도수해유청단백배방내대고변태반응풍험인동발생변태반응성질병적예방작용,급기대인동체격생장발육적영향。방법선취2012년10월지2013년10월우덕양시인민의원산과출생급삼가인동보건문진적구유고변태반응풍험적184례인동위연구대상,채용수궤수자표법장기분위간예조(n=91)화비간예조(n=93)。간예조인동접수순모유위양+괄도수해유청단백배방내적음식간예,비간예조인동미접수특수음식간예。본연구준순적정서부합덕양시인민의원인체시험위원회소제정적윤리학표준,득도해위원회비준,분조정득수시대상감호인적지정동의,병여지첨서림상연구지정동의서。관찰량조인동변태반응성습진적발생정황,비교량조인동재불동수방시간점적체격생장발육상황。결과량조환인일반정황비교,차이균무통계학의의(P >0.05)。수방6,12개월시,간예조인동변태반응성습진발생솔화엄중정도균소우비간예조(P <0.05)。수방3,6,9,12개월시,량조인동체질량、신장、체질지수(BMI)비교,차이균무통계학의의(P >0.05)。결론채용모유위양+괄도수해유청단백배방내적음식간예능강저고변태반응풍험인동적변태반응성습진발생솔급기엄중정도,대기체격생장발육무영향。
Objective To explore the effects of partially whey protein hydrolyzed formula on prevention of eczema and physical growth in high risk infants.Methods From October 2012 to 2013, a total of 184 high risk infants were included in the study.They were randomly divided into intervention group(n = 91 )and non-intervention group (n = 93 ).Breast feeding + partially whey protein hydrolyzed formula were taken in intervention group.Regular formula was taken in non-intervention group.The study protocol was approved by the Ethical Review Board of Investigation in Human Being of People′s Hospital of Deyang City.Informed consent was obtained from each participants′s parents.The incidence rate of eczema were observed in both groups,and the physical growth,including the weight,height and body mass index (BMI),were evaluated between two groups.Results At 6 months and 12 months follow-up,the incidence rate and the severity of eczema in the intervention group were significantly lower than those of non-intervention group(P <0.05 ).There were no significant differences on the physical growth between two groups(P > 0.05 ).Conclusions Partially hydrolyzed whey formula can reduces the incidence rate and severity of eczema in high risk infants.Meanwhile it also can maintain the normal growth of high risk infants.