CAJ | 학술논문

背景：纳米羟基磷灰石/聚酰胺66复合物在力学属性方面和人体皮质骨十分接近，且具有成骨活性，是一种安全可靠的骨材料。目的：探讨纳米羟基磷灰石/聚酰胺66复合生物活性支撑材料在恢复椎体结构和高度中的作用。方法：纳入177例脊柱疾病患者，其中男116例，女61例，年龄17-81岁，包括97例脊柱骨折、5例脊柱原发性肿瘤、17例脊柱结核及58例颈椎病，均实施前路减压纳米羟基磷灰石/聚酰胺66复合生物活性支撑体植骨融合内固定治疗。治疗后随访36个月，进行影像学分析、Frankel脊髓损伤分级、植骨融合、目测类比评分、JOA及SF-36评分评估。结果与结论：经随访，除1例颈椎骨折患者在术后出现轻微支撑体移位之外，其余患者均未出现支撑体脱出或破裂现象，植骨融合率为96.0%，平均支撑体下沉距离为1.7 mm；与治疗前比较，脊柱骨折97例患者治疗后的神经功能得到有不同程度改善(P <0.05)；177例患者的目测类比评分、JOA评分及SF-36评分较治疗前显著改善(P <0.05)。表明在脊柱重建过程中使用纳米羟基磷灰石/聚酰胺66复合生物活性支撑材料可提高植骨融合率，有效恢复椎体结构和高度。
배경：납미간기린회석/취선알66복합물재역학속성방면화인체피질골십분접근，차구유성골활성，시일충안전가고적골재료。목적：탐토납미간기린회석/취선알66복합생물활성지탱재료재회복추체결구화고도중적작용。방법：납입177례척주질병환자，기중남116례，녀61례，년령17-81세，포괄97례척주골절、5례척주원발성종류、17례척주결핵급58례경추병，균실시전로감압납미간기린회석/취선알66복합생물활성지탱체식골융합내고정치료。치료후수방36개월，진행영상학분석、Frankel척수손상분급、식골융합、목측류비평분、JOA급SF-36평분평고。결과여결론：경수방，제1례경추골절환자재술후출현경미지탱체이위지외，기여환자균미출현지탱체탈출혹파렬현상，식골융합솔위96.0%，평균지탱체하침거리위1.7 mm；여치료전비교，척주골절97례환자치료후적신경공능득도유불동정도개선(P <0.05)；177례환자적목측류비평분、JOA평분급SF-36평분교치료전현저개선(P <0.05)。표명재척주중건과정중사용납미간기린회석/취선알66복합생물활성지탱재료가제고식골융합솔，유효회복추체결구화고도。
BACKGROUND:Nanohydroxyapatite/polyamide 66 composite is very close to the human cortical bone in terms of mechanical properties, and has osteogenic activity, which is a safe and reliable bone material. OBJECTIVE:To investigate the effect of nanohydroxyapatite/polyamide 66 composite bioactive supporting material on the restoration of vertebral structure and height. METHODS: Totaly 177 patients with spinal diseases, 116 males and 61 females, aged 17-81 years, were enroled, including 97 cases of spinal fractures, 5 cases of primary tumors of the spine, 17 cases of spinal tuberculosis and 58 cases of cervical spondylosis. The nanohydroxyapatite/polyamide 66 composite bioactive supporting body was filed into the bone grafts of patients and then subjected to anterior decompression and internal fixation. After 36 months of folow-up, imaging analysis, Frankel spinal cord injury classification, bone graft fusion, visual analog scale scores,Short Form 36 and Japanese Orthopedic Association scores were evaluated. RESULTS AND CONCLUSION:During the folow-up, except one patient with cervical spine fracture appeared to have slight supporting body displacement, there was no supporting body prolapse or rupture phenomena. The bone graft fusion rate was 96.0%, the average supporting body sinking distance was 1.7 mm. After treatment, 97 patients with spinal fractures had different degree of improvement in the neurological function (P < 0.05); the visual analog scale scores, Short Form 36 and Japanese Orthopedic Association scores were improved significantly in al the 177 patients compared with before treatment (P < 0.05). These results demonstrate that the use of nanohydroxyapatite/polyamide 66 composite bioactive supporting material for spinal reconstruction can improve the bone fusion rate, and restore the vertebral structure and height effectively.