中国实用神经疾病杂志
中國實用神經疾病雜誌
중국실용신경질병잡지
Chinese Journal of Practical Nervous Diseases
2015年
21期
16-17,18
,共3页
急性脑卒中%血清%瘦素%神经功能
急性腦卒中%血清%瘦素%神經功能
급성뇌졸중%혈청%수소%신경공능
Acute stroke%Serum%Leptin%Nerve function
目的：探讨急性脑卒中患者血清瘦素的水平变化及对神经功能康复的影响。方法随机选取急性脑卒中患者80例为实验组，60例正常体检者为对照组，所有患者均于入院次日空腹采用放射免疫法检测其血清瘦素水平并测体重指数。据急性脑卒中患者的体重指数将患者分为过轻、正常、适中、过重、肥胖、非常肥胖6个亚组，治疗30 d后用美国国立卫生研究院卒中量表（National institute of health stroke scale ，NIHSS ）检测6个亚组的神经功能情况。结果实验组血清瘦素水平较对照组明显升高（P＜0.01），且患者血清瘦素的水平越高，治疗30 d的 NIHSS 评分越高（r＝0.937、0.650、0.638、0.837、0.914、0.889，t＝6.013、3.825、3.796、4.593、5.521、5.146，P＜0.001）。结论急性脑卒中患者血清瘦素水平较正常人明显升高，且血清瘦素水平越高，神经功能康复情况越差；可在一定程度上预测患者的神经功能康复水平，并指导临床治疗，进一步提高康复程度。
目的：探討急性腦卒中患者血清瘦素的水平變化及對神經功能康複的影響。方法隨機選取急性腦卒中患者80例為實驗組，60例正常體檢者為對照組，所有患者均于入院次日空腹採用放射免疫法檢測其血清瘦素水平併測體重指數。據急性腦卒中患者的體重指數將患者分為過輕、正常、適中、過重、肥胖、非常肥胖6箇亞組，治療30 d後用美國國立衛生研究院卒中量錶（National institute of health stroke scale ，NIHSS ）檢測6箇亞組的神經功能情況。結果實驗組血清瘦素水平較對照組明顯升高（P＜0.01），且患者血清瘦素的水平越高，治療30 d的 NIHSS 評分越高（r＝0.937、0.650、0.638、0.837、0.914、0.889，t＝6.013、3.825、3.796、4.593、5.521、5.146，P＜0.001）。結論急性腦卒中患者血清瘦素水平較正常人明顯升高，且血清瘦素水平越高，神經功能康複情況越差；可在一定程度上預測患者的神經功能康複水平，併指導臨床治療，進一步提高康複程度。
목적：탐토급성뇌졸중환자혈청수소적수평변화급대신경공능강복적영향。방법수궤선취급성뇌졸중환자80례위실험조，60례정상체검자위대조조，소유환자균우입원차일공복채용방사면역법검측기혈청수소수평병측체중지수。거급성뇌졸중환자적체중지수장환자분위과경、정상、괄중、과중、비반、비상비반6개아조，치료30 d후용미국국립위생연구원졸중량표（National institute of health stroke scale ，NIHSS ）검측6개아조적신경공능정황。결과실험조혈청수소수평교대조조명현승고（P＜0.01），차환자혈청수소적수평월고，치료30 d적 NIHSS 평분월고（r＝0.937、0.650、0.638、0.837、0.914、0.889，t＝6.013、3.825、3.796、4.593、5.521、5.146，P＜0.001）。결론급성뇌졸중환자혈청수소수평교정상인명현승고，차혈청수소수평월고，신경공능강복정황월차；가재일정정도상예측환자적신경공능강복수평，병지도림상치료，진일보제고강복정도。
Objective To investigate serum leptin levels in acute stroke patients and its impact on neurological rehabilita‐tion. Methods We randomly selected 80 patients with acute stroke as the experimental group and 60 healthy individuals as the control group. The fasting serum leptin was determined by radioimmunoassay and the body mass index was measured in all par‐ticipants the next day after admission. All patients with acute stroke were divided into six levels of underweight ,normal ,mod‐erate ,overweight ,obese and hyper‐obese subgroup according to body mass index. Then we detected neurological conditions of six subgroups based on NIHSS after 30‐day treatment. Results The serum leptin levels in the experimental group were signifi‐cantly higher than that in the control group (P<0.01) ,and the higher the patients had the levels of serum leptin ,the higher NIHSS scores were after 30‐day treatment (r=0.937 ,0.650 ,0.638 ,0.837 ,0.914 ,0.889 ;t=6.013 ,3.825 ,3.796 ,4.593 , 5.521 ,5.146 ,P<0.001).Conclusion Serum leptin levels in patients with acute stroke are significantly higher than that in controls ,and the higher the serum leptin levels ,the worse the situation neurological rehabilitation ,which can predict the level of the patient's neurological rehabilitation to some extent ,and can guide clinical treatment to improve the degree of recovery.
