中国实用神经疾病杂志
中國實用神經疾病雜誌
중국실용신경질병잡지
Chinese Journal of Practical Nervous Diseases
2015年
21期
8-10
,共3页
青年缺血性脑卒中%甲状腺自身免疫性抗体%颅内大动脉狭窄
青年缺血性腦卒中%甲狀腺自身免疫性抗體%顱內大動脈狹窄
청년결혈성뇌졸중%갑상선자신면역성항체%로내대동맥협착
Ischemic stroke%Thyroid autoimmune antibodies%Intracranial large artery stenosis
目的：探讨青年缺血性脑卒中患者甲状腺自身免疫性抗体检测的临床意义，为临床进一步认识甲状腺自身免疫性抗体与颅内大动脉狭窄（ILAS）之间的关系提供参考。方法回顾性分析2012‐04－2014‐04来我院诊治的青年缺血性脑卒中甲状腺功能正常的350例患者资料，根据临床确认颅内大动脉狭窄（ILAS）症状120例，无颅内大动脉狭窄（Non‐ILAS）的症状230例。比较2组甲状腺功能及甲状腺自身免疫性抗体，分析青年缺血性脑卒中患者出现颅内大动脉狭窄的独立性因素。结果 ILAS组患者的年龄明显高于对照组，房颤的发生率显著低于对照组，各项指标差异有统计学意义（P＜0.05），其他临床资料无差异；2组TSH、TT3、TT4及fT3、fT4均在正常范围内，差异无统计学意义（P＞0.05），而实验组 TPOAb阳性率与TGAb阳性率明显高于对照组，差异有统计学意义（P＜0.05）；采用Logistic逐步回归分析得知，TPOAb阳性率（OR＝3.651）、TGAb阳性率（OR＝3.371）、年龄（OR＝2.803）及房颤（OR＝2.946）等因素是青年缺血性脑卒中患者出现颅内大动脉狭窄的独立性因素。结论甲状腺自身免疫性抗体与青年缺血性脑卒中患者存在颅内大动脉狭窄的独立因素，提示免疫机制可能在颅内大动脉狭窄中起作用。
目的：探討青年缺血性腦卒中患者甲狀腺自身免疫性抗體檢測的臨床意義，為臨床進一步認識甲狀腺自身免疫性抗體與顱內大動脈狹窄（ILAS）之間的關繫提供參攷。方法迴顧性分析2012‐04－2014‐04來我院診治的青年缺血性腦卒中甲狀腺功能正常的350例患者資料，根據臨床確認顱內大動脈狹窄（ILAS）癥狀120例，無顱內大動脈狹窄（Non‐ILAS）的癥狀230例。比較2組甲狀腺功能及甲狀腺自身免疫性抗體，分析青年缺血性腦卒中患者齣現顱內大動脈狹窄的獨立性因素。結果 ILAS組患者的年齡明顯高于對照組，房顫的髮生率顯著低于對照組，各項指標差異有統計學意義（P＜0.05），其他臨床資料無差異；2組TSH、TT3、TT4及fT3、fT4均在正常範圍內，差異無統計學意義（P＞0.05），而實驗組 TPOAb暘性率與TGAb暘性率明顯高于對照組，差異有統計學意義（P＜0.05）；採用Logistic逐步迴歸分析得知，TPOAb暘性率（OR＝3.651）、TGAb暘性率（OR＝3.371）、年齡（OR＝2.803）及房顫（OR＝2.946）等因素是青年缺血性腦卒中患者齣現顱內大動脈狹窄的獨立性因素。結論甲狀腺自身免疫性抗體與青年缺血性腦卒中患者存在顱內大動脈狹窄的獨立因素，提示免疫機製可能在顱內大動脈狹窄中起作用。
목적：탐토청년결혈성뇌졸중환자갑상선자신면역성항체검측적림상의의，위림상진일보인식갑상선자신면역성항체여로내대동맥협착（ILAS）지간적관계제공삼고。방법회고성분석2012‐04－2014‐04래아원진치적청년결혈성뇌졸중갑상선공능정상적350례환자자료，근거림상학인로내대동맥협착（ILAS）증상120례，무로내대동맥협착（Non‐ILAS）적증상230례。비교2조갑상선공능급갑상선자신면역성항체，분석청년결혈성뇌졸중환자출현로내대동맥협착적독립성인소。결과 ILAS조환자적년령명현고우대조조，방전적발생솔현저저우대조조，각항지표차이유통계학의의（P＜0.05），기타림상자료무차이；2조TSH、TT3、TT4급fT3、fT4균재정상범위내，차이무통계학의의（P＞0.05），이실험조 TPOAb양성솔여TGAb양성솔명현고우대조조，차이유통계학의의（P＜0.05）；채용Logistic축보회귀분석득지，TPOAb양성솔（OR＝3.651）、TGAb양성솔（OR＝3.371）、년령（OR＝2.803）급방전（OR＝2.946）등인소시청년결혈성뇌졸중환자출현로내대동맥협착적독립성인소。결론갑상선자신면역성항체여청년결혈성뇌졸중환자존재로내대동맥협착적독립인소，제시면역궤제가능재로내대동맥협착중기작용。
Objective To investigate the clinical effect of thyroid‐induced autoimmune antibodies on young ischemic stroke patients to provide clinical evidence and possible relationship between thyroid‐induced autoimmune antibodies and intracranial large artery stenosis (ILAS). Methods We retrospectively analyzed the clinical data of 350 ischemic stroke patients with nor‐mal thyroid function from April 2012 to April 2014 in our hospital ,among who 120 cases were clinically diagnosed with ILAS (the study group) and 230 cases were conformed without ILAS (the control group). Then we observed the difference of clinical data ,comparatively analyzed the thyroid function and thyroid‐induced autoimmune antibodies of two groups ,and researched in‐dependent risk factors of ILAS. Results The clinical data of two groups revealed that the study group had older age and higher incidence of atrial fibrillation than the control group with significant differences (P<0.05) ,while other clinical data showed no significant differences. All of TSH ,TT3 ,TT4 and fT3 ,fT4 of two groups were with the normal limits with no difference (P>0.05). While positive rates of TPOAb and TGAb in study group were significantly higher than those in the control group , there were significant differences (P<0.05);Logistic regression analysis showed that independent risk factors of ILAS includ‐ed TPOAb positive rate (OR= 3.651) ,TGAb positive rate (OR= 3.371) ,age (OR= 2.803) and atrial fibrillation (OR=2.946) and other factors in young ischemic stroke patients.Conclusion Thyroid‐induced autoimmune antibodies may be the in‐dependent risk factors of ILAS in young ischemic stroke patients ,which indicates that the immune system may play a role in in‐tracranial artery stenosis.
