CAJ | 학술논문

程序性死亡分子-1（PD-1）是T淋巴细胞膜表面表达的负向协同刺激分子，与其主要配体（PD-L1）形成通路后，可以减弱T淋巴细胞的免疫反应，甚至导致T淋巴细胞功能衰竭。PD-1/PD-L1信号通路在乙型肝炎病毒感染后的效应T细胞免疫耐受中具有重要作用，阻断该途径可能是抗病毒治疗的方向之一，具有良好的应用前景。
정서성사망분자-1（PD-1）시T림파세포막표면표체적부향협동자격분자，여기주요배체（PD-L1）형성통로후，가이감약T림파세포적면역반응，심지도치T림파세포공능쇠갈。PD-1/PD-L1신호통로재을형간염병독감염후적효응T세포면역내수중구유중요작용，조단해도경가능시항병독치료적방향지일，구유량호적응용전경。
Programmed cell death-1 (PD-1),as an inhibitory co-stimulatory molecule,is expressed on the surface of T lymphocyte membranes. After interacting with its main ligand,programmed death-1 ligand (PD-L1),PD-1 decreases immune re-sponse of T lymphocytes,and even damages the overall functioning of T lymphocytes. PD-1/PD-L1 signaling pathway plays an important role in the tolerance of T cell immune response triggered by hepatitis B virus infection. Studies indicate that blocking this pathway may provide an new insights into antiretroviral therapy,and might be a promising applications in clinical practice.