CAJ | 학술논문

背景：自固化磷酸钙人工骨Ⅱ型与重组人骨形态发生蛋白均有一定的成骨诱导作用，存在修复腱骨界面损伤的可能。目的：探讨自固化磷酸钙人工骨Ⅱ型的成骨诱导作用及修复腱骨界面损伤生物力学情况。方法：35只成年健康的新西兰白兔，随机选取5只，处死后取双侧肩关节腱骨界面标本作为正常对照。剩余30只构建腱骨界面损伤模型后，随机等分为实验组和模型组，模型组不填塞任何药物，实验组填塞自固化磷酸钙人工骨Ⅱ型进行修复。结果与结论：填塞自固化磷酸钙人工骨Ⅱ型后，兔损伤腱骨界面明显恢复，且随时间的延长，修复效果更佳，骨形态发生蛋白2表达水平也随之增加，损伤腱骨界面最大抗拉强度以及最大刚度明显增加。表明利用自固化磷酸钙人工骨Ⅱ型复合重组人骨形态发生蛋白对腱骨界面损伤进行修复具有良好的成骨诱导作用，可以促进损伤的修复。
배경：자고화린산개인공골Ⅱ형여중조인골형태발생단백균유일정적성골유도작용，존재수복건골계면손상적가능。목적：탐토자고화린산개인공골Ⅱ형적성골유도작용급수복건골계면손상생물역학정황。방법：35지성년건강적신서란백토，수궤선취5지，처사후취쌍측견관절건골계면표본작위정상대조。잉여30지구건건골계면손상모형후，수궤등분위실험조화모형조，모형조불전새임하약물，실험조전새자고화린산개인공골Ⅱ형진행수복。결과여결론：전새자고화린산개인공골Ⅱ형후，토손상건골계면명현회복，차수시간적연장，수복효과경가，골형태발생단백2표체수평야수지증가，손상건골계면최대항랍강도이급최대강도명현증가。표명이용자고화린산개인공골Ⅱ형복합중조인골형태발생단백대건골계면손상진행수복구유량호적성골유도작용，가이촉진손상적수복。
BACKGROUND:Both calcium phosphate cement II and recombinant human bone morphogenetic protein have certain osteoinductive effects, which have the possibility of repairing tendon-bone interface injury. OBJECTIVE: To investigate the osteoinductive effect of calcium phosphate cement II and its biomechanics analysis of repairing tendon-bone interface injury. METHODS:Five out of 35 adult healthy New Zealand white rabbits were randomly selected and their bilateral shoulder joint tendon-bone interface specimens were taken as normal control group after being sacrificed. The remaining 30 rabbits were used to make animal models of tendon-bone interface injury and then randomly divided into experimental and model groups. Rabbits in the model group had no treatment, and those in the experimental group were treated with calcium phosphate cement II. RESULTS AND CONCLUSION: After repair with calcium phosphate cement II, the injured tendon-bone interface of rabbits was obviously restored, and the repair effect became better with time. The expression level of bone morphogenetic protein 2 was also increased accordingly. The maximum tensile strength and the maximum stiffness of the injured tendon-bone interface were obviously increased. These results demonstrate that calcium phosphate cement II combined with recombinant human bone morphogenetic protein has good osteoinductive and repair effect in repair of tendon-bone interface injury.