CAJ | 학술논문

目的：探讨明胶海绵颗粒与Embosphere生物微球栓塞治疗原发性肝癌破裂出血的效果。方法回顾分析近5年来收治的49例（使用明胶海绵23例，使用Embosphere生物微球26例）经导管肝动脉明胶海绵和Embosphere生物微球栓塞治疗的原发性肝癌破裂出血患者的临床资料，评价即时止血和再次出血率。结果明胶海绵组和Embosphere生物微球组即时止血率均为100%；在明胶海绵栓塞治疗后7天内再次出血率为13.0%（3/23），1例转外科手术，1例再次介入治疗，术后成功止血，1例因突发失血性休克死亡；在Embosphere生物微球栓塞后7天内再次出血率为3.8%（1/26），显著低于明胶海绵组（P<0.01）。结论明胶海绵和Embosphere生物微球治疗肝癌破裂出血即时止血效果相同，但Embosphere生物微球治疗术后再出血风险明显减少。
목적：탐토명효해면과립여Embosphere생물미구전새치료원발성간암파렬출혈적효과。방법회고분석근5년래수치적49례（사용명효해면23례，사용Embosphere생물미구26례）경도관간동맥명효해면화Embosphere생물미구전새치료적원발성간암파렬출혈환자적림상자료，평개즉시지혈화재차출혈솔。결과명효해면조화Embosphere생물미구조즉시지혈솔균위100%；재명효해면전새치료후7천내재차출혈솔위13.0%（3/23），1례전외과수술，1례재차개입치료，술후성공지혈，1례인돌발실혈성휴극사망；재Embosphere생물미구전새후7천내재차출혈솔위3.8%（1/26），현저저우명효해면조（P<0.01）。결론명효해면화Embosphere생물미구치료간암파렬출혈즉시지혈효과상동，단Embosphere생물미구치료술후재출혈풍험명현감소。
Objective To explore the efficacy of the gelatin sponge particle and embosphere microsphere embolization for the treatment of patients with hepatocellular carcinoma and tumor rupture. Methods 49 patients with rupture of hepatocellular carcinoma underwent transcatheter arterial embolization by gelatin sponge particle (n =23) or embosphere microsphere (n =26) embolization in recent 5 years,and instant hemostatic and rehaemorrhagia rates were compared. Results There was no difference between gelatin sponge particle and embosphere microsphere embolization on the effects of instant hemostatic (both were 100%);Seven days after intervention,the rehaemorrhagia rate in gelatin sponge particles was 13.0%(3/23),one patient was transferred to surgery,one patient was re-intervened and one patient dead because of haemorrhagic shock,respectively;The rehaemorrhagia rate in embosphere microspheres group was 3.8%(1/26,P<0.01),and the patient received re-intervention and the bleeding was stopped successfully. Conclusion The instant hemostatic effect is the same between the gelatin sponge particle and embosphere microspheres embolization in patients with rupture of hepatocellular carcinoma,however,the embosphere group has much less chance to rebleeding within 7 days.