浙江化工
浙江化工
절강화공
Zhejiang Chemical Industry
2015年
10期
15-17
,共3页
球磨%缬沙坦%2-氰基-4-溴甲基联苯%L-缬氨酸甲酯盐酸盐
毬磨%纈沙坦%2-氰基-4-溴甲基聯苯%L-纈氨痠甲酯鹽痠鹽
구마%힐사탄%2-청기-4-추갑기련분%L-힐안산갑지염산염
ball milling%valsartan%L -valine methyl ester hydrochloride%4 -bromomethyl -2 -cyanobiphenyl
报道了以L-缬氨酸甲酯盐酸盐和2'-氰基-4-溴甲基联苯为基本原料经球磨法合成缬沙坦的关键中间体(S)-3-{[2'-氰基联苯-4-基]甲基}缬氨酸甲酯盐酸盐的工艺,收率92%. 本工艺反应时间短,收率高,无溶剂,环境友好,具有较好的应用前景.
報道瞭以L-纈氨痠甲酯鹽痠鹽和2'-氰基-4-溴甲基聯苯為基本原料經毬磨法閤成纈沙坦的關鍵中間體(S)-3-{[2'-氰基聯苯-4-基]甲基}纈氨痠甲酯鹽痠鹽的工藝,收率92%. 本工藝反應時間短,收率高,無溶劑,環境友好,具有較好的應用前景.
보도료이L-힐안산갑지염산염화2'-청기-4-추갑기련분위기본원료경구마법합성힐사탄적관건중간체(S)-3-{[2'-청기련분-4-기]갑기}힐안산갑지염산염적공예,수솔92%. 본공예반응시간단,수솔고,무용제,배경우호,구유교호적응용전경.
(S)-3-{[2'-cyanobiphenyl-4-yl] methyl}valine methyl ester hydrochloride was synthesized from L-valine methyl ester hydrochloride and 4-bromomethyl-2-cyanobiphenyl with an overall yield of about 92%. The advantages of this method are: shorter reaction time,high yields, solvent free, environmentally friendly and its general applicability.
