CAJ | 학술논문

为开发利用珊瑚真菌资源，以徐闻珊瑚保护区珊瑚样品中分离鉴定的43株海洋真菌为研究对象，采用双层平板法和Ellman法分别对其进行抗菌和乙酰胆碱酯酶（ AChE）抑制活性筛选。结果显示，43株菌株至少对一种指示菌有抑制作用，且有12株菌株对革兰阳性菌和革兰阴性菌均表现出不同程度的抗菌活性，抗菌谱较广；当浓度为1 mg/mL时，有8株菌株的发酵液提取物对乙酰胆碱酯酶的抑制率达到50%以上。其活性菌株中曲霉属（ Aspergillus）为优势属。
위개발이용산호진균자원，이서문산호보호구산호양품중분리감정적43주해양진균위연구대상，채용쌍층평판법화Ellman법분별대기진행항균화을선담감지매（ AChE）억제활성사선。결과현시，43주균주지소대일충지시균유억제작용，차유12주균주대혁란양성균화혁란음성균균표현출불동정도적항균활성，항균보교엄；당농도위1 mg/mL시，유8주균주적발효액제취물대을선담감지매적억제솔체도50%이상。기활성균주중곡매속（ Aspergillus）위우세속。
Inordertodevelopcoralfungiresources,theantibacterialandAChEinhibitoryactivitiesof43marinefun-gi isolated from Xuwen Coral National Nature Preserved Area were determined by agar diffusion assay and Ellman methods,respectively. The results showed that 43 strains of fungi had antibacterial activity against at least one indica-tor strain,among them twelve strains were found to have different degree of antibiotic activities against both Gram-pos-itive bacteria and Gram-negative bacteria with fairly broad antibiogram;when the concentration was at 1 mg/mL,the extracts of fermentation broth from eight strains showed that the AChE inhibition rates were more than 50%. Aspergil-lus strains were the dominant genus among these active strains.