CAJ | 학술논문

目的：探讨成年早期的体重状态及至中年时期的体重变化与中年时期高甘油三酯（TG）血症之间的关系。 　　方法：选取参加1998年我国大规模心血管病危险因素调查的15组人群样本，每个人群整群抽样约1000人，其年龄在35~59岁（定义为中年时期），男女各半，询问研究对象25岁时（定义为成年早期时）的体重，进行心血管病危险因素调查，根据研究对象25岁时的体重和调查时的身高，计算其25岁时的体重指数（BMI）；研究对象成年早期按BMI水平分为4组：低体重组（BMI<18.5 kg/m2）、正常体重组（BMI：18.5~23.9 kg/m2）、超重组（BMI：24~27.9 kg/m2）、和肥胖组（BMI≥28 kg/m2）。25岁至中年时期的体重变化为现测体重减去25岁时体重，根据体重变化将研究对象分为<-7.5 kg组、-7.5~-2.6 kg组、-2.5~2.5 kg组、2.6~7.5 kg组、7.6~12.5 kg组和＞12.5 kg组共6组。分别探讨25岁时的体重状态和随后的体重变化与高TG血症的关系。 　　结果：共有13883人纳入分析，研究对象按BMI水平的4个分组中年时期高TG血症患病率分别为22.8％、26.0％、27.4％和30.8％，呈明显上升趋势（趋势检验P<0.01）。25岁至中年时期的体重的6组研究对象的高TG血症患病率分别为12.5％、14.0％、17.8％、24.2％、31.5％和40.9％，也呈明显上升趋势（趋势检验P<0.01）。多因素Logistic回归结果显示，25岁时的超重和肥胖以及随后的体重增加均与中年时期高TG血症正相关（趋势检验P<0.01）。 　　结论：成年早期的超重和肥胖以及随后的体重增加均与中年时期罹患高TG血症独立相关。
목적：탐토성년조기적체중상태급지중년시기적체중변화여중년시기고감유삼지（TG）혈증지간적관계。 　　방법：선취삼가1998년아국대규모심혈관병위험인소조사적15조인군양본，매개인군정군추양약1000인，기년령재35~59세（정의위중년시기），남녀각반，순문연구대상25세시（정의위성년조기시）적체중，진행심혈관병위험인소조사，근거연구대상25세시적체중화조사시적신고，계산기25세시적체중지수（BMI）；연구대상성년조기안BMI수평분위4조：저체중조（BMI<18.5 kg/m2）、정상체중조（BMI：18.5~23.9 kg/m2）、초중조（BMI：24~27.9 kg/m2）、화비반조（BMI≥28 kg/m2）。25세지중년시기적체중변화위현측체중감거25세시체중，근거체중변화장연구대상분위<-7.5 kg조、-7.5~-2.6 kg조、-2.5~2.5 kg조、2.6~7.5 kg조、7.6~12.5 kg조화＞12.5 kg조공6조。분별탐토25세시적체중상태화수후적체중변화여고TG혈증적관계。 　　결과：공유13883인납입분석，연구대상안BMI수평적4개분조중년시기고TG혈증환병솔분별위22.8％、26.0％、27.4％화30.8％，정명현상승추세（추세검험P<0.01）。25세지중년시기적체중적6조연구대상적고TG혈증환병솔분별위12.5％、14.0％、17.8％、24.2％、31.5％화40.9％，야정명현상승추세（추세검험P<0.01）。다인소Logistic회귀결과현시，25세시적초중화비반이급수후적체중증가균여중년시기고TG혈증정상관（추세검험P<0.01）。 　　결론：성년조기적초중화비반이급수후적체중증가균여중년시기리환고TG혈증독립상관。
Objective: To explore the relationship between body weight changes from early adulthood to middle age and the prevalence of hypertriglyceridemia by large-scale cardiovascular risk factor investigation. Methods: A total of 15 population groups from China multi-center collaborative study of cardiovascular epidemiology in 1998 were enrolled. There were approximately 1000 participants in each group including 50% of each male and female at the age of (35-59) years which was deifned as middle age. The participants were surveyed for cardiovascular risk factors including the body weight and body mass index (BMI) at the age of 25 years which was deifned as early adulthood. The participants were divided into 4 groups based on BMI at early adulthood: Low body weight group, BMI < 18.5 kg/m2, Normal body weight group, BMI (18.5-23.9) kg/m2, Overweight group, BMI (24-27.9) kg/m2 and Obese group, BMI ≥ 28 kg/m2. The changes of body weight from early adulthood to middle age were calculated by body weight at present minus body weight at 25 years; according to the differences, participants were divided into another set of 6 groups: differences < -7.5 kg, (-7.5 to -2.6) kg, (-2.5 to 2.5) kg, (2.6 to7.5) kg, (7.6 to 12.5) kg and > 12.5 kg. The relationship between body weight status at 25 years of age with subsequent changes and the prevalence of hypertriglyceridemia were investigated. Results: A total of 13883 participants finished the investigation.①The prevalence of hypertriglyceridemia by 4 BMI groups were at 22.8%, 26.0%, 27.4% and 30.8% respectively (the trend ofP<0.01).②The prevalence of hypertriglyceridemia by 6 age differences groups were at 12.5 %, 14.0 %, 17.8 %, 24.2 %, 31.5 % and 40.9 % respectively (the trend ofP<0.01). Multivariate Logistic regression analysis indicated that overweight and obesity at the age of 25 years with subsequent weight gain were positively related to the risk of hypertriglyceridemia at the middle age (the trend ofP<0.01). Conclusion: Overweight and obesity in early adulthood with subsequent weight gain were independently related to the risk of hypertriglyceridemia at the middle age in our survey.