河北北方学院学报（自然科学版）
河北北方學院學報（自然科學版）
하북북방학원학보（자연과학판）
Journal of Hebei North University (Natural Science Edition)
2015年
5期
69-72
,共4页
非糖尿病维持性血液透析%甲状腺激素%FT3
非糖尿病維持性血液透析%甲狀腺激素%FT3
비당뇨병유지성혈액투석%갑상선격소%FT3
nondiabetic hemodialysis%thyroid hormone%FT3
目的：探讨非糖尿病维持性血液透析（MHD）患者甲状腺激素水平变化、低 T3综合征发生率及其相关因素。方法选取68例 MHD 患者为透析组，同期肾内科门诊随诊的53例非糖尿病慢性肾脏病（CKD 2～3期）患者为对照组，利用电化学发光法、免疫比浊法测定血清白蛋白、血肌酐、血红蛋白、胆固醇、甘油三酯、C 反应蛋白、甲状腺激素、甲状旁腺激素水平等并进行相关性分析，观察 MHD 患者低 T3综合征发生率及相关因素。结果 MHD 患者甲状腺激素水平异常发生率较高，其中以低 T3综合征（low T3 synbrome）最为常见；透析组 FT3平均水平为（3.31±1.45）pmol·L-1，对照组 FT3平均水平（4.19±1.42）pmol·L-1；相关性分析表明 FT3水平与血肌酐、血白蛋白、年龄、Hb 显著相关，与血压、血脂异常、血糖、性别及血浆纤维蛋白原（FIB）无显著相关性。结论 MHD 患者甲状腺激素水平异常多见，其中以低 T3综合征最为常见；FT3水平与血白蛋白、血肌酐、年龄、Hb 显著相关。
目的：探討非糖尿病維持性血液透析（MHD）患者甲狀腺激素水平變化、低 T3綜閤徵髮生率及其相關因素。方法選取68例 MHD 患者為透析組，同期腎內科門診隨診的53例非糖尿病慢性腎髒病（CKD 2～3期）患者為對照組，利用電化學髮光法、免疫比濁法測定血清白蛋白、血肌酐、血紅蛋白、膽固醇、甘油三酯、C 反應蛋白、甲狀腺激素、甲狀徬腺激素水平等併進行相關性分析，觀察 MHD 患者低 T3綜閤徵髮生率及相關因素。結果 MHD 患者甲狀腺激素水平異常髮生率較高，其中以低 T3綜閤徵（low T3 synbrome）最為常見；透析組 FT3平均水平為（3.31±1.45）pmol·L-1，對照組 FT3平均水平（4.19±1.42）pmol·L-1；相關性分析錶明 FT3水平與血肌酐、血白蛋白、年齡、Hb 顯著相關，與血壓、血脂異常、血糖、性彆及血漿纖維蛋白原（FIB）無顯著相關性。結論 MHD 患者甲狀腺激素水平異常多見，其中以低 T3綜閤徵最為常見；FT3水平與血白蛋白、血肌酐、年齡、Hb 顯著相關。
목적：탐토비당뇨병유지성혈액투석（MHD）환자갑상선격소수평변화、저 T3종합정발생솔급기상관인소。방법선취68례 MHD 환자위투석조，동기신내과문진수진적53례비당뇨병만성신장병（CKD 2～3기）환자위대조조，이용전화학발광법、면역비탁법측정혈청백단백、혈기항、혈홍단백、담고순、감유삼지、C 반응단백、갑상선격소、갑상방선격소수평등병진행상관성분석，관찰 MHD 환자저 T3종합정발생솔급상관인소。결과 MHD 환자갑상선격소수평이상발생솔교고，기중이저 T3종합정（low T3 synbrome）최위상견；투석조 FT3평균수평위（3.31±1.45）pmol·L-1，대조조 FT3평균수평（4.19±1.42）pmol·L-1；상관성분석표명 FT3수평여혈기항、혈백단백、년령、Hb 현저상관，여혈압、혈지이상、혈당、성별급혈장섬유단백원（FIB）무현저상관성。결론 MHD 환자갑상선격소수평이상다견，기중이저 T3종합정최위상견；FT3수평여혈백단백、혈기항、년령、Hb 현저상관。
Objective To make correlation analysis on non-diabetic hemodialysis patients with thyroid hormone levels and the incidence of euthyriod sick syndrome.Methods 68 cases with non-diabetic dialysis from our hospital were selected from August 2013 to April 2015,while for the control group,53cases with non-diabetic chronic kidney disease (CKD 2~3 stage)were selected from nephrology outpatients in same period.By electrochemical luminescence and immune turbidimetric methods,serum albumin,serum creatinine,hemoglobin,glucose,cholesterol,triglyceride,HDL cholesterol,LDL cholesterol,C-reac-tive protein,thyroid hormone,blood calcium,phosphorus and parathyroid hormone levels were meas-ured.At the same time,SPSS 19.0 software package was used for independent samples t-test,correla-tion analysis and Logistic regression analysis.Thyroid hormone levels in non-diabetic patients with carotid atherosclerosis were made by correlation analysis,and maintenance hemodialysis observation was made as well.Results More than one change in thyroid hormone levels in non-diabetic hemodialysis patients exis-ted with low triiodothyronine level as the most common.Mean FT3 level of non-diabetic hemodialysis pa-tients was (3.31±1.45)pmol·L-1 ,which was significantly lower than that of control group with mean FT3 level (4.19±1.42)pmol·L-1 .For analysis on risk factors,in multivariate Logistic regression anal-ysis with the change of FT3 levels,serum albumin,serum creatinine,age and hemoglobin were signifi-cantly correlated.Conclusion More than one change in thyroid hormone levels in non-diabetic hemodialy-sis patients existed with low triiodothyronine level as the most common.FT3 levels were significantly cor-related with serum albumin,serum creatinine,age and hemoglobin.
