CAJ | 학술논문

目的:探究补中益气汤对胃部功能性疾病的具体治疗效果与作用机制.方法:以ICC作为观察对象和实验设计的切入点,建立有关模拟力竭心身应激的大鼠以及小鼠动物模型并观察各组动物模型中的实验变化情况,同时对动物模型疾病多发的胃窦部进行实验取材并通过Real-Time qPCR检测基因表达的变化.结果:通过观察研究发现动物模型的体重一直呈现缓慢增长的趋势,大、小鼠模型的抗疲劳能力有所下降且胃肠道功能紊乱,而补中益气汤则恰好可以缓解动物模型脾虚的症状,尤其是在显微镜下观察到补中益气汤可以在一定程度上有效控制应激性上升而导致ICC损伤增大的现象.结论:肠胃功能紊乱会对ICC的组织结构和功能在一定程度上造成影响,而补中益气汤却可以有效改善上述变化,有效降低由于疾病而造成的对ICC的损害程度,因此可以说补中益气汤可以通过调节ICC的变化进而有效控制胃肠功能紊乱的症状.
목적:탐구보중익기탕대위부공능성질병적구체치료효과여작용궤제.방법:이ICC작위관찰대상화실험설계적절입점,건립유관모의력갈심신응격적대서이급소서동물모형병관찰각조동물모형중적실험변화정황,동시대동물모형질병다발적위두부진행실험취재병통과Real-Time qPCR검측기인표체적변화.결과:통과관찰연구발현동물모형적체중일직정현완만증장적추세,대、소서모형적항피로능력유소하강차위장도공능문란,이보중익기탕칙흡호가이완해동물모형비허적증상,우기시재현미경하관찰도보중익기탕가이재일정정도상유효공제응격성상승이도치ICC손상증대적현상.결론:장위공능문란회대ICC적조직결구화공능재일정정도상조성영향,이보중익기탕각가이유효개선상술변화,유효강저유우질병이조성적대ICC적손해정도,인차가이설보중익기탕가이통과조절ICC적변화진이유효공제위장공능문란적증상.
Objective:To explore effects of the Buzhong Yiqi Decoction on the stomach functional diseases and the mechanism.Methods: ICC were observed as the starting point,the establishment of relevant simulation exhaustion of psychosomatic stress in rats and mice,and multiple gastric antrum experiment and drawn through real-time qPCR gene expression changes were recorded.Results: Through the study,found that the weight of the animal model has been showing a trend of slow growth,anti fatigue ability of mouse and rat model has decreased gastrointestinal disorders,andthe decoction can alleviate the symptoms of spleen deficiency,also can control stress and lead to the ICC damage.Conclusion: In gastrointestinal disorders,the Buzhong Yiqi Decoction can effectively improve the changes,effectively reducing due to disease of the ICC damage.