CAJ | 학술논문

目的:观察补脾温肾汤对慢性肾炎脾肾阳虚证患者临床疗效及机制.方法:将 70 例慢性肾炎脾肾阳虚证患者随机分为治疗组35例和对照组35例.治疗组采取中药补脾温肾汤治疗;对照组则采取贝那普利治疗.两组疗程均为8周.治疗8周后对两组临床治疗效果进行比较,并观察治疗前后两组24 h尿蛋白和血清转化生长因子(TGF-β1)水平的变化.结果:治疗后,治疗组总有效率 85.7%,对照组总有效率 80.0%,两组无显著性差异(P>0.05);治疗组中医证候疗效总有效率 88.9%,对照组中医证候疗效总有效率69.4%,治疗组在改善中医症候方面疗效优于对照组(P<0.05).两组均能显著降低24 h尿蛋白定量,且治疗组优于对照组(P<0.01).两组均能显著降低血清TGF-β1,且治疗组优于对照组(P<0.05).结论:补脾温肾汤能明显改善慢性肾炎脾肾阳虚证患者的临床症状,减轻蛋白尿,下调血清转化生长因子β1(TGF-β1)的水平.
목적:관찰보비온신탕대만성신염비신양허증환자림상료효급궤제.방법:장 70 례만성신염비신양허증환자수궤분위치료조35례화대조조35례.치료조채취중약보비온신탕치료;대조조칙채취패나보리치료.량조료정균위8주.치료8주후대량조림상치료효과진행비교,병관찰치료전후량조24 h뇨단백화혈청전화생장인자(TGF-β1)수평적변화.결과:치료후,치료조총유효솔 85.7%,대조조총유효솔 80.0%,량조무현저성차이(P>0.05);치료조중의증후료효총유효솔 88.9%,대조조중의증후료효총유효솔69.4%,치료조재개선중의증후방면료효우우대조조(P<0.05).량조균능현저강저24 h뇨단백정량,차치료조우우대조조(P<0.01).량조균능현저강저혈청TGF-β1,차치료조우우대조조(P<0.05).결론:보비온신탕능명현개선만성신염비신양허증환자적림상증상,감경단백뇨,하조혈청전화생장인자β1(TGF-β1)적수평.
Objective: To observe clinical effect and mechanism of the Bupi WenShen decoction on chronic nephritis.Methods:70 patients with chronic nephritis of Pishe Yangxu were randomly divided into two groups,and each group of 35 cases.The control group was given lotensin,while the treatment group was given BuPi WenShen decoction.Results: After treatment,the total efficiency of the treatment group was 85.7% and in the control group was 80.0% (P>0.05) ; the total eficiency of syndromes were 88.9% in treatment group and 69.4% in control group,respectively.The clinical efficiency in treatment group was better (P<0.05).Both groups could significantly reduce the 24-h urinary albumin,and the treatment group was better than the control group (P<0.01).Both groups could significantly reduce the levels of serum TGF-β1,and the treatment group was better (P<0.05 ).Conclusions: BuPi WenShen Decoction could attenuate the albuminuria in patients with chronic nephritis.