CAJ | 학술논문

目的：探讨血清中肿瘤坏死因子α（TNF-α）及白细胞介素6（IL-6）水平的改变与肥胖的相关性及其对精液常规参数的影响。方法选择2015年1月—2015年5月于山西省妇幼保健院生殖医学中心就诊的男性患者324例为研究对象，将324例研究对象分为低体质量组、正常组、超重组及肥胖组，对各组患者行精液常规参数、精子形态、精浆锌含量、精子顶体酶活性及血清TNF-α及IL-6水平检测。同时就血清TNF-α及IL-6水平与精液常规参数之间进行相关性分析。结果低体质量组、超重组及肥胖组与正常组相比，前向运动精子百分率均显著下降，差异有统计学意义。肥胖组与正常组相比，头部缺陷精子显著增多，差异有统计学意义。而低体质量组及超重组与正常组相比精子形态差异无统计学意义。肥胖组与正常体质量组相比，精浆锌含量及精子顶体酶活性显著降低，差异有统计学意义。低体质量组及超重组与正常体质量组相比差异无统计学意义。超重与肥胖组患者血清中TNF-α及IL-6含量与正常体质量组相比均显著升高，差异有统计学意义。低体质量组与正常体组相比，血清中TNF-α及IL-6含量均差异无统计学意义。血清TNF-α及IL-6水平与男性精液密度及前向运动精子间存在相关性，而血清TNF-α及IL-6水平与患者精液量间未见相关性。结论男性肥胖患者体内不仅TNF-α及IL-6水平升高，而且与男性精液密度及前向运动精子率下降存在一定的相关性。
목적：탐토혈청중종류배사인자α（TNF-α）급백세포개소6（IL-6）수평적개변여비반적상관성급기대정액상규삼수적영향。방법선택2015년1월—2015년5월우산서성부유보건원생식의학중심취진적남성환자324례위연구대상，장324례연구대상분위저체질량조、정상조、초중조급비반조，대각조환자행정액상규삼수、정자형태、정장자함량、정자정체매활성급혈청TNF-α급IL-6수평검측。동시취혈청TNF-α급IL-6수평여정액상규삼수지간진행상관성분석。결과저체질량조、초중조급비반조여정상조상비，전향운동정자백분솔균현저하강，차이유통계학의의。비반조여정상조상비，두부결함정자현저증다，차이유통계학의의。이저체질량조급초중조여정상조상비정자형태차이무통계학의의。비반조여정상체질량조상비，정장자함량급정자정체매활성현저강저，차이유통계학의의。저체질량조급초중조여정상체질량조상비차이무통계학의의。초중여비반조환자혈청중TNF-α급IL-6함량여정상체질량조상비균현저승고，차이유통계학의의。저체질량조여정상체조상비，혈청중TNF-α급IL-6함량균차이무통계학의의。혈청TNF-α급IL-6수평여남성정액밀도급전향운동정자간존재상관성，이혈청TNF-α급IL-6수평여환자정액량간미견상관성。결론남성비반환자체내불부TNF-α급IL-6수평승고，이차여남성정액밀도급전향운동정자솔하강존재일정적상관성。
Objective Toinvestigatethepotentialeffectofover-weightandobesityonsemenqualitymediated TNF-αand IL-6. Methods According to the body mass index values we divided 324 male cases into low-weight group, normal weight group,over-weight group and obese group.Then we determined the semen parameters,sperm morphology, sperm DNA integrity, spermatozoa acrosin activity, seminal plasma zinc, and serum TNF-α and IL-6 levels. Results Compared with normal weight group,the progressive motility in low-weight,over-weight and obese groups was significantly decreased. However, the abnormal head rate in obese group was significantly increased. The sperm spermatozoa acrosin activity and seminal plasma zinc concentration were found significantly decreased in obese group.The serum TNF-αand IL-6 levels were significantly increased in over-weight group and obese group.Both progressive motility and sperm concentration have a nonlinear association with the levels of serum TNF-αand IL-6. Conclusion The decrease in semen quality caused by over-weight and obesity may be mediated by serum TNF-αand IL-6 levels.