CAJ | 학술논문

攻克肿瘤最有潜力的方法是基因治疗,目前研究最多的是以聚乙烯亚胺(PEI)及其衍生物为病毒载体的非病毒基因疗法.虽然聚乙烯亚胺越来越多地应用于非病毒基因递送系统,但它仍存在不足之处,需作出进一步的研究和改进,主要可从以下方面来进行改进:筛选合适的 PEI,连接屏蔽基团,连接靶向配体,引入核定位信号和拟病毒颗粒模式等.本文主要介绍一些新的研究策略及改进措施.
공극종류최유잠력적방법시기인치료,목전연구최다적시이취을희아알(PEI)급기연생물위병독재체적비병독기인요법.수연취을희아알월래월다지응용우비병독기인체송계통,단타잉존재불족지처,수작출진일보적연구화개진,주요가종이하방면래진행개진:사선합괄적 PEI,련접병폐기단,련접파향배체,인입핵정위신호화의병독과립모식등.본문주요개소일사신적연구책략급개진조시.
The most promising treatment for cancer was gene therapy. In recent years, the non-viral gene therapy which PEI and its derivatives were selected as viral vector were researched widely. Although poly ethylene imine was increasingly used in non-viral gene delivery systems, it still obtain shortcomings, need to make further research and improvement, mainly from the following aspects: screening suitable PEI, connecting to the shield group, linking to a targeting ligand, and introducing nuclear localization signal and virus particles mode. In this article, some new research strategies and improvement measures were introduced.