CAJ | 학술논문

目的：研究参橘止咳滴丸的止咳祛痰作用。方法：采用小鼠氨水引咳、豚鼠枸橼酸引咳和电刺激豚鼠喉上神经引咳、小鼠气管段酚红排出法和大鼠气管毛细玻管排痰法等实验方法评价参橘止咳滴丸的止咳祛痰作用。结果：与正常对照组比较，参橘止咳滴丸各剂量组在延长实验动物的咳嗽潜伏期，减少其咳嗽次数，缩短豚鼠电刺激呼吸恢复时间，增加酚红排出量和排痰量等方面，差异有统计学意义(P＜0.05)。与阳性对照（急支糖浆）组比较，参橘止咳滴丸中、大剂量组在延长实验动物的潜伏期，减少其咳嗽次数，缩短豚鼠电刺激呼吸恢复时间，增加酚红排出量和排痰量等方面，差异有统计学意义(P＜0.05)。结论：参橘止咳滴丸具有明显的止咳祛痰作用，且其中、大剂量组疗效优于急支糖浆组。
목적：연구삼귤지해적환적지해거담작용。방법：채용소서안수인해、돈서구연산인해화전자격돈서후상신경인해、소서기관단분홍배출법화대서기관모세파관배담법등실험방법평개삼귤지해적환적지해거담작용。결과：여정상대조조비교，삼귤지해적환각제량조재연장실험동물적해수잠복기，감소기해수차수，축단돈서전자격호흡회복시간，증가분홍배출량화배담량등방면，차이유통계학의의(P＜0.05)。여양성대조（급지당장）조비교，삼귤지해적환중、대제량조재연장실험동물적잠복기，감소기해수차수，축단돈서전자격호흡회복시간，증가분홍배출량화배담량등방면，차이유통계학의의(P＜0.05)。결론：삼귤지해적환구유명현적지해거담작용，차기중、대제량조료효우우급지당장조。
Objective:To study antitussive and expectorant effects of ShenJu ZhiKe dripping pills. Methods:Antitussive and expectorant effects of ShenJu ZhiKe dripping pills were evaluated by the experiments of mice with cough induced by ammonia, guinea pig with cough induced by citric acid, guinea pig with cough induced by elec-tricity stimulated superior laryngeal nerve, tracheal phenol red excretion test of the mice, capillary glass-tube expec-toration method of the rats and other methods. Results:The difference indicated statistical meaning in the compari-son of prolonging cough incubation period of experimental animals, reducing cough times, shortening breathing re-covery time of guinea pig induced by electrical stimulation, increasing phenol red excretion amount and expectora-tion amount when different doses groups of ShenJu ZhiKe dripping pills were compared with normal control group (P<0.05). The difference demonstrated statistical meaning in the comparison of prolong incubation period of experi-mental animals, shortening breathing recovery time of guinea pig induced by electrical stimulation, increasing phe-nol red excretion amount and expectoration amount when moderate and high doses groups of ShenJu ZhiKe dripping pills were compared with positive control group (JiZhi syrup) (P<0.05). Conclusion:ShenJu ZhiKe dripping pills show obvious antitussive and expectorant effects, and high dose group is superior to JiZhi syrup group in clinical effects.