CAJ | 학술논문

目的：探讨抗菌药物不合理使用与药物不良反应发生的相关性。方法选取2013年1月至2014年11月云南省临沧市镇康县人民医院诊治的药物不良反应患者62例，收集患者临床资料，对其使用的抗菌药物类型、用药途径、不良反应发生及其表现形式、部位等进行统计分析。结果喹诺酮类药物引发的不良反应发生率最高，其次为β-内酰胺类抗生素；不良反应主要累及皮肤及软组织，其次为消化系统；抗菌药物不合理使用主要为用药时间过长、滴速过快、剂量过大、药液浓度过高；Person相关性分析结果显示，用药时间过长、滴速过快、剂量过大、药液浓度过高与抗菌药物的各不良反应发生均呈正相关。结论应用抗菌药物前应详细了解使用药物的适应证、禁忌证、可能出现的不良反应等，使用时合理控制药物的剂量和浓度、用药时间、输药速度，并加强医护双方监测，以减少不良反应的发生。
목적：탐토항균약물불합리사용여약물불량반응발생적상관성。방법선취2013년1월지2014년11월운남성림창시진강현인민의원진치적약물불량반응환자62례，수집환자림상자료，대기사용적항균약물류형、용약도경、불량반응발생급기표현형식、부위등진행통계분석。결과규낙동류약물인발적불량반응발생솔최고，기차위β-내선알류항생소；불량반응주요루급피부급연조직，기차위소화계통；항균약물불합리사용주요위용약시간과장、적속과쾌、제량과대、약액농도과고；Person상관성분석결과현시，용약시간과장、적속과쾌、제량과대、약액농도과고여항균약물적각불량반응발생균정정상관。결론응용항균약물전응상세료해사용약물적괄응증、금기증、가능출현적불량반응등，사용시합리공제약물적제량화농도、용약시간、수약속도，병가강의호쌍방감측，이감소불량반응적발생。
Objective To investigate the relationship between the irrational use of antibiotics and the occurrence of adverse drug reactions.Methods November January 2013 to 2014 Yunnan Province Lincang zhenkang County People's Hospital for diagnosis and treatment of adverse drug reactions in patients with 62 patients were selected to col ect clinical data of the patients,to carry on the statistical analysis to the the use of antibacterial drug type,route of administration,adverse reactions occur rate and adverse reaction of form and location.Results Quinolone induced adverse reaction rate was the highest,fol owed by beta lactam antibiotics;adverse reactions mainly involving the skin and soft tissue.Secondly,for the digestive system;unreasonable use of antibacterial drugs mainly medication for a long time,speed too fast,the dose is too large,the high drug concentration;Pearson correlation analysis showed that,medi-cation for a long time,speed is too fast,excessive dosage,high drug concentration and antibacterial drugs,the adverse reactions were positively correlated.Conclusion In order to reduce the occurrence of adverse reactions,the use of antibiotics should be used to understand the use of drugs,the indications,the possible adverse reactions,and so on.