CAJ | 학술논문

骨桥蛋白（osteopontion, OPN）是胞外基质中具有多种功能的分泌型糖蛋白，既可作为一种粘附蛋白，参与肿瘤细胞粘附、迁移；又可作为一种细胞因子，促进肿瘤血管形成、逃避免疫监视及抑制细胞凋亡。CD44v糖蛋白是细胞表面粘附分子之一，介导细胞-基质和细胞-细胞间相互作用。近年来大量研究表明OPN及其受体CD44v促进肿瘤侵袭转移，其血清水平与多种肿瘤的预后相关。因此，阐明OPN在肿瘤演进的分子机制及其信号通路有助于寻找一种新颖抗癌疗法。
골교단백（osteopontion, OPN）시포외기질중구유다충공능적분비형당단백，기가작위일충점부단백，삼여종류세포점부、천이；우가작위일충세포인자，촉진종류혈관형성、도피면역감시급억제세포조망。CD44v당단백시세포표면점부분자지일，개도세포-기질화세포-세포간상호작용。근년래대량연구표명OPN급기수체CD44v촉진종류침습전이，기혈청수평여다충종류적예후상관。인차，천명OPN재종류연진적분자궤제급기신호통로유조우심조일충신영항암요법。
Osteopontin (OPN) is a multifunctional, extracellular matrix-associated, secretory, glyco-protein. It can be used as an adhesion protein involved in tumor cell adhesion,migration; but also as a cytokine, promoting tumor angiogen-esis, evading immune surveillance and inhibiting cellular apoptosis. CD44v glycoprotein, is one of the cell surface adhesion molecule that mediates cell-matrix and cell-cell interactions. Extensive research has suggested the important role of OPN in regulating signaling pathways that contribute to tumor progression and metastasis, and the serum level is associated with the prognosis of various malignancies. hTerefore, clarifying OPN in the molecular mechanisms of tumor progression and its signal-ing pathway contributes to seeking a novel anti-cancer therapy.