CAJ | 학술논문

目的：探讨健脾化湿汤联合清肠栓对脾虚湿热型溃疡性结肠炎（UC）患者生存质量的影响。方法收集脾虚湿热型UC 患者65例，随机分为治疗组32例，采用健脾化湿汤联合清肠栓治疗，对照组33例，采用健脾化湿汤治疗。治疗8周后，评价患者炎症性肠病生存质量问卷（IBDQ）、健康调查简表（SF-36）积分、肠镜计分和中医症状改善情况。结果在 IBDQ 总分、肠道症状（B）维度、一般健康状况（GH）维度评价方面，治疗组优于对照组（P ＜0．05）；治疗组总有效率100％，对照组总有效率83．33％，2组间比较无统计学意义（P ＞0．05）；单项症状脓血便、腹痛、里急后重症状比较，治疗组优于对照组（P ＜0．05）。肠道黏膜 Baron 评分，2组间比较无统计学意义（P ＞0．05）。结论健脾化湿汤联合清肠栓的内外合治法能有效改善脾虚湿热型溃疡性结肠炎患者的生存质量。
목적：탐토건비화습탕연합청장전대비허습열형궤양성결장염（UC）환자생존질량적영향。방법수집비허습열형UC 환자65례，수궤분위치료조32례，채용건비화습탕연합청장전치료，대조조33례，채용건비화습탕치료。치료8주후，평개환자염증성장병생존질량문권（IBDQ）、건강조사간표（SF-36）적분、장경계분화중의증상개선정황。결과재 IBDQ 총분、장도증상（B）유도、일반건강상황（GH）유도평개방면，치료조우우대조조（P ＜0．05）；치료조총유효솔100％，대조조총유효솔83．33％，2조간비교무통계학의의（P ＞0．05）；단항증상농혈편、복통、리급후중증상비교，치료조우우대조조（P ＜0．05）。장도점막 Baron 평분，2조간비교무통계학의의（P ＞0．05）。결론건비화습탕연합청장전적내외합치법능유효개선비허습열형궤양성결장염환자적생존질량。
OBJECTIVE To study the effect of Jianpihuashi Decoction combined with Chinese Herbal Medicine Qingchang-shuan on life quality of spleen-deficiency and dampness-heat type patients with ulcerative colitis(UC).METHODS 65 Patients were recruited with UC and belong to spleen-deficiency and dampness-heat type and were randomly divided into the treatment group and the control group,with 32 cases in treatment group(Jianpihuashi Decoction combined with Chinese Herbal Medicine Qingchangshuan),and 33 cases in control group(Jianpihuashi Decoction).The treatment lasted for 8 weeks.The Inflammato-ry Bowel Disease Questionnaire(IBDQ),Short Form 36 Health Survey Questionnaire(SF 36),Enteroscopy Scores and Symp-tom Scores of Traditional Chinese Medicine were recorded before and after the treatment.RESULTS The record of treatment group had better reaction than the control group in IBDQ,bowel symptoms scale (B),and general health(GH)(P <0.05). The effective rate in treatment group was 100%,which in the control group was 83.33%.And there was no statistical signifi-cance(P >0.05) between two groups.Additionally,treatment group showed better reactions than control group in individual symptom,such as stool with blood and pus,abdominal pain and rectal tenesmus and there was statistical significance between two groups(P <0.05).After the treatment,there was no statistical significance in Baron grade between two groups(P >0.05).CONCLUSION Jianpihuashi Decoction combined with Chinese Herbal Medicine Qingchangshuan can better improve the life quality of patients with ulcerative colitis(UC)and belong to spleen-deficiency and dampness-heat type than Jianpihuashi Decoction only.