CAJ | 학술논문

目的：探讨健康成人的糖代谢调节状态与血清25羟维生素D3[25（OH）D]水平的关系。方法102名健康成人根据稳态模型评估的胰岛B细胞功能指数（ HOMA－B）、胰岛素分泌指数（ IS）、胰岛素敏感性指数（ IAI）、胰岛素抵抗指数（HOMA－IR）这四个指标来评价其糖代谢调节状态，并根据其血清25（OH）D水平分为25（ OH） D降低组和正常组，比较2组的临床资料，对呈非正态分布的25（ OH） D、HOMA－B、IS、HOMA－IR进行对数转换，通过Pearson相关分析和多重线性回归探讨糖代谢指标与血清25（OH）D水平的关系。结果64例（62．7％）受试者的血清25（ OH ） D 水平降低，25（ OH ） D 降低组的Lg（HOMA－B）、Lg（IS）、IAI均显著低于正常组（P＜0．05），Lg（HOMA－IR）显著高于正常组（P＜0．05）。 Lg[25（OH）D]与Lg（HOMA－B）、Lg（IS）、IAI成正相关（P＜0．05），与Lg（HOMA－IR）成负相关（P＜0．05）。结论25（OH）D有利于提高胰岛B细胞的功能及胰岛素的敏感性，血清25（ OH） D水平降低的人群可适当补充维生素D。
목적：탐토건강성인적당대사조절상태여혈청25간유생소D3[25（OH）D]수평적관계。방법102명건강성인근거은태모형평고적이도B세포공능지수（ HOMA－B）、이도소분비지수（ IS）、이도소민감성지수（ IAI）、이도소저항지수（HOMA－IR）저사개지표래평개기당대사조절상태，병근거기혈청25（OH）D수평분위25（ OH） D강저조화정상조，비교2조적림상자료，대정비정태분포적25（ OH） D、HOMA－B、IS、HOMA－IR진행대수전환，통과Pearson상관분석화다중선성회귀탐토당대사지표여혈청25（OH）D수평적관계。결과64례（62．7％）수시자적혈청25（ OH ） D 수평강저，25（ OH ） D 강저조적Lg（HOMA－B）、Lg（IS）、IAI균현저저우정상조（P＜0．05），Lg（HOMA－IR）현저고우정상조（P＜0．05）。 Lg[25（OH）D]여Lg（HOMA－B）、Lg（IS）、IAI성정상관（P＜0．05），여Lg（HOMA－IR）성부상관（P＜0．05）。결론25（OH）D유리우제고이도B세포적공능급이도소적민감성，혈청25（ OH） D수평강저적인군가괄당보충유생소D。
Objective To investigate the relationship between the state of sugar metabolic regulation and serum 25 -hydroxyl Vitamin D3[25(OH)D] levels of healthy adult. Methods A total of 102 healthy adults who were received health examination in our hospital were enroll for the study.Their state of sugar metabolic regulation were evalua-ted through the homeostasis model assessment B cell function index ( HOMA-B) , secretion index ( IS ) , the sensitive index ( IAI ) , and insulin resistance index ( HOMA-IR).Healthy adults cases were divid-ed into the 25( OH) D reduction group and normal group according to the serum 25 ( OH ) D level. Clinical data were compared between two groups.25 ( OH ) D, HOMA-B, IS, HOMA -IR followed abnormal distribution were analyzed by logarithmic transformation. Pearson correlation analysis and multiple linear regression analysis were performed to investigate the relationship between the index of sugar metabolic regulation and serum 25-hydroxyl Vitamin D3 levels. Results The serum 25(OH)D level of 64 cases (62.7%) decreased.Lg(HOMA-B), Lg(IS), IAI of the 25(OH)D reduction group were significantly higher than those of normal group ( P<0.05 ) , and Lg ( HOMA -IR ) was significantly lower than that of normal group(P<0.05).Lg[25(OH)D] was positively correlated with Lg(HOMA-B), Lg(IS),IAI(P<0.05),andnegativelycorrelatedwithLg(HOMA-IR)(P<0.05).Conclusion 25(OH)D could improve the function of pancreatic islet B cell and sensitivity of insulin, thus the adults with decreased serum 25 ( OH) D level are advised to receive appropriate VD supplement.