CAJ | 학술논문

目的：通过不同剂量、不同时间的米索前列醇阴道给药，观察其在晚期妊娠引产中的临床疗效和安全性，探索米索前列醇阴道用药的剂量和方法。方法180例符合引产指征的足月妊娠妇女随机分为6组，其中5组分别阴道内放置米索前列醇引产，剂量和时间分别为12．5μg q6 h（ A组），25μg q6 h（ B组），25μg q12 h（C组），50μg q6 h（D组），50μg q12 h（E组），1组为对照组，静脉点滴催产素引产。结果 A组24，48 h引产成功率低于对照组，B、C、D、E组引产成功率均高于对照组（P＜0．05），4组间差异无统计学意义（P＞0．05）。 A、B、C、D、E组剖宫产率低于对照组，阴道分娩率高于对照组（ P＜0．05）；B、C、D、E组产程显著短于对照组（ P＜0．01）；B、C组引产48 h成功率差异无统计学意义（P＞0．05）。结论25μgq6h米索前列醇引产成功率高，阴道分娩率高，剖宫产率低且宫缩过强，且不良反应发生率低，为临床值得推荐的剂量和方法。
목적：통과불동제량、불동시간적미색전렬순음도급약，관찰기재만기임신인산중적림상료효화안전성，탐색미색전렬순음도용약적제량화방법。방법180례부합인산지정적족월임신부녀수궤분위6조，기중5조분별음도내방치미색전렬순인산，제량화시간분별위12．5μg q6 h（ A조），25μg q6 h（ B조），25μg q12 h（C조），50μg q6 h（D조），50μg q12 h（E조），1조위대조조，정맥점적최산소인산。결과 A조24，48 h인산성공솔저우대조조，B、C、D、E조인산성공솔균고우대조조（P＜0．05），4조간차이무통계학의의（P＞0．05）。 A、B、C、D、E조부궁산솔저우대조조，음도분면솔고우대조조（ P＜0．05）；B、C、D、E조산정현저단우대조조（ P＜0．01）；B、C조인산48 h성공솔차이무통계학의의（P＞0．05）。결론25μgq6h미색전렬순인산성공솔고，음도분면솔고，부궁산솔저차궁축과강，차불량반응발생솔저，위림상치득추천적제량화방법。
Objective To observe the clinical effect and safety of miso-prostol in the treatment of induced labor of late pregnancy by different dosage and different time through vaginal delivery, and explore the dos-age and method of misoprostol vaginal delivery.Methods A total of 180 cases in induced labor indications of full term pregnant women were ran-domly divided into six groups, including five groups for medicines, re-spectively using vaginal placing misoprostol in induced labor, dosage and time were 12.5 μg q6 h ( A group ) , 25 μg q6 h ( B group ) , 25 μg q12 h ( C group) , 50μg q6 h ( D group) , 50μg q12 h ( E group) , an-other group of intravenous drip of oxytocin induced labor group ( control group) .Results The success rate of 24 h and 48 h to induced labor in A group was lower than that of control group, but B, C, D, E groups were higher than control group(P<0.05), no significant differences be-tween B, C, D, E groups( P>0.05); the rate of cesarean section in medicines groups were lower than that of control group, and the rate of viginal delivery were higher than that of control group ( P<0.05 ); the stages of labor in B, C, D, and E groups were significantly shorter than that of control group ( P <0.01 ); 48 h success rate of 25 μg induced labor was no difference between B and C groups ( P >0.05 ) . Conclusion Patients in B group had a high success rate of induced la-bor and high vaginal delivery rate, too low cesarean section rate and low rate of side effects such as contractions and amniotic fluid.Thus, 25 μg q6 h misoprostol is the recommended dose and method for patients.