CAJ | 학술논문

结核是严重危害人们健康的重大公共问题。早期诊断结核有利于控制结核的传播和降低结核的死亡率。目前常用的诊断方法存在假阳性和假阴性，并有敏感度和特异性不高、价格昂贵、耗时等缺点。微小 RNA（microRNA，miRNA）是近十多年来新兴的生物标记物，多项研究表明 miRNAs 与疾病密切相关，在疾病的进展中发挥着重要作用。通过对结核感染后 miRNA 的表达谱变化以及 miRNA 诊断结核的特异度和敏感性进行分析，能够找到一种快速、无创、有效的早期诊断结核的分子指标，为临床结核诊治以及结核感染机制研究提供一种新的思路。本文就结核感染后循环血miRNA的表达水平变化以及其诊断结核的特异度和敏感性进行综述。
결핵시엄중위해인문건강적중대공공문제。조기진단결핵유리우공제결핵적전파화강저결핵적사망솔。목전상용적진단방법존재가양성화가음성，병유민감도화특이성불고、개격앙귀、모시등결점。미소 RNA（microRNA，miRNA）시근십다년래신흥적생물표기물，다항연구표명 miRNAs 여질병밀절상관，재질병적진전중발휘착중요작용。통과대결핵감염후 miRNA 적표체보변화이급 miRNA 진단결핵적특이도화민감성진행분석，능구조도일충쾌속、무창、유효적조기진단결핵적분자지표，위림상결핵진치이급결핵감염궤제연구제공일충신적사로。본문취결핵감염후순배혈miRNA적표체수평변화이급기진단결핵적특이도화민감성진행종술。
Tuberculosis (TB) is a serious disease that affects people all over the world. Early diagnosis can effectively control TB infection and decrease the mobility. There are some shortcomings including false positive, false negative, low sensitivity, low specificity, expensive and time wasting of recent diagnostic methods. MiRNA is a new biomarker which closely related in many diseases, and plays an important role in the progress of these diseases. The analysis of profile and diagnostic value of miRNAs after Mycobacterium tuberculosis (M.tb) infection could help us to find a new, non-invasive, effective and early diagnostic biomarker for TB. It could also provide a new idea to study the diagnosis, treatment and the mechanism of TB infection. The article reviewed the expression level of circulating miRNAs after M.tb infection and analyzed the sensitivity and specificity of miRNAs for diagnosis of TB.