中华临床医师杂志(电子版)
中華臨床醫師雜誌(電子版)
중화림상의사잡지(전자판)
Chinese Journal of Clinicians (Electronic Edition)
2015年
20期
3733-3737
,共5页
Fournier坏疽%因果律%死亡率%并发症
Fournier壞疽%因果律%死亡率%併髮癥
Fournier배저%인과률%사망솔%병발증
Fournier gangrene%Causality%Mortality%Complication
目的:分析 Fournier 坏疽患者的易患因素、并发症和病死率的关系。方法收集2002~2013年我院接诊的58例Fournier坏疽患者的临床资料。回顾两组患者年龄、性别、易患因素、并发症、临床和实验室资料、病死率等,分析易患因素和并发症对病死率的影响,对预后相关因素进行统计分析。结果高病死率见于糖尿病(12/24,50.00%),心功能不全(10/18,55.56%),脓毒血症(15/29,51.72%),血流动力学不稳定(15/31,48.39%),血钠降低(14/15,93.33%),肌肉受累(11/12,91.67%),腹壁感染(14/22,63.64%)。生存组与死亡组比较,以下方面显示出明显的统计学差异:年龄[(42.5±2.1)岁vs.(63.2±2.8)岁,P<0.001],脓毒症状态(93.75%vs.33.33%, P<0.001),血流动力学不稳定(93.75%vs.38.10%,P<0.001),血钠降低(87.50%vs.23.81%, P<0.001),肌肉受累(68.75%vs.2.38%,P<0.001),腹壁感染(87.50%vs.19.00%,P<0.001),糖尿病(75.00%vs.28.57%,P<0.05)。肌酸激酶增高[(393.23±4.81)U/L vs.(512.57±6.35)U/L, t=91.60,P<0.001],乳酸增高[(2.41±1.12)mmol/L vs.(10.83±2.34)mmol/L,t=20.49,P<0.001],抗凝血酶Ⅲ降低[(62.85±5.20)%vs.(47.72±3.98)%,t=11.58,P<0.001],也是明显的死亡预后因素。结论 Fournier坏疽具有病死率高的特点,在处理该类患者时,需严密监测并控制易患因素,积极对症处理预后相关的并发症,综合治疗,才能降低病死率。
目的:分析 Fournier 壞疽患者的易患因素、併髮癥和病死率的關繫。方法收集2002~2013年我院接診的58例Fournier壞疽患者的臨床資料。迴顧兩組患者年齡、性彆、易患因素、併髮癥、臨床和實驗室資料、病死率等,分析易患因素和併髮癥對病死率的影響,對預後相關因素進行統計分析。結果高病死率見于糖尿病(12/24,50.00%),心功能不全(10/18,55.56%),膿毒血癥(15/29,51.72%),血流動力學不穩定(15/31,48.39%),血鈉降低(14/15,93.33%),肌肉受纍(11/12,91.67%),腹壁感染(14/22,63.64%)。生存組與死亡組比較,以下方麵顯示齣明顯的統計學差異:年齡[(42.5±2.1)歲vs.(63.2±2.8)歲,P<0.001],膿毒癥狀態(93.75%vs.33.33%, P<0.001),血流動力學不穩定(93.75%vs.38.10%,P<0.001),血鈉降低(87.50%vs.23.81%, P<0.001),肌肉受纍(68.75%vs.2.38%,P<0.001),腹壁感染(87.50%vs.19.00%,P<0.001),糖尿病(75.00%vs.28.57%,P<0.05)。肌痠激酶增高[(393.23±4.81)U/L vs.(512.57±6.35)U/L, t=91.60,P<0.001],乳痠增高[(2.41±1.12)mmol/L vs.(10.83±2.34)mmol/L,t=20.49,P<0.001],抗凝血酶Ⅲ降低[(62.85±5.20)%vs.(47.72±3.98)%,t=11.58,P<0.001],也是明顯的死亡預後因素。結論 Fournier壞疽具有病死率高的特點,在處理該類患者時,需嚴密鑑測併控製易患因素,積極對癥處理預後相關的併髮癥,綜閤治療,纔能降低病死率。
목적:분석 Fournier 배저환자적역환인소、병발증화병사솔적관계。방법수집2002~2013년아원접진적58례Fournier배저환자적림상자료。회고량조환자년령、성별、역환인소、병발증、림상화실험실자료、병사솔등,분석역환인소화병발증대병사솔적영향,대예후상관인소진행통계분석。결과고병사솔견우당뇨병(12/24,50.00%),심공능불전(10/18,55.56%),농독혈증(15/29,51.72%),혈류동역학불은정(15/31,48.39%),혈납강저(14/15,93.33%),기육수루(11/12,91.67%),복벽감염(14/22,63.64%)。생존조여사망조비교,이하방면현시출명현적통계학차이:년령[(42.5±2.1)세vs.(63.2±2.8)세,P<0.001],농독증상태(93.75%vs.33.33%, P<0.001),혈류동역학불은정(93.75%vs.38.10%,P<0.001),혈납강저(87.50%vs.23.81%, P<0.001),기육수루(68.75%vs.2.38%,P<0.001),복벽감염(87.50%vs.19.00%,P<0.001),당뇨병(75.00%vs.28.57%,P<0.05)。기산격매증고[(393.23±4.81)U/L vs.(512.57±6.35)U/L, t=91.60,P<0.001],유산증고[(2.41±1.12)mmol/L vs.(10.83±2.34)mmol/L,t=20.49,P<0.001],항응혈매Ⅲ강저[(62.85±5.20)%vs.(47.72±3.98)%,t=11.58,P<0.001],야시명현적사망예후인소。결론 Fournier배저구유병사솔고적특점,재처리해류환자시,수엄밀감측병공제역환인소,적겁대증처리예후상관적병발증,종합치료,재능강저병사솔。
Objective To determine predisposing factors or complications and mortality of patients with Fournier’s gangrene. Methods Data of 58 Fournier’s gangrene patients (treated in our hospital from 2002 to 2013) were evaluated retrospectively. Data of age gender, predisposing factors, complication, clinical and laboratory findings and mortality were collected retrospectively. To analyse the effect of predisposing factors and complications to mortality rates. Results An increase in the mortality could be seen in patients with diabetes mellitus (12/24, 50.00%), cardiac insufficiency (10/18, 55.56%), a septic condition at presentation (15/29, 51.72%), hemodynamic instability (15/31, 48.39%), low serum sodium levels (14/15, 93.33%), muscular involvement (11/12, 91.67%), and the abdomen was affected (14/22, 63.64%). The comparison between the survivors and the nonsurvivors showed a statistical significance for the factor age [(42.5±2.1) years vs. (63.2±2.8) years, P<0.001], a septic condition at presentation (93.75%vs. 33.33%, P<0.001), hemodynamic instability (93.75%vs. 38.10%, P<0.001), low serum sodium levels (87.50%vs. 23.81%, P<0.001), muscular involvement (68.75%vs. 2.38%, P<0.001) and abdominal affection (87.50% vs. 19.00%, P<0.001), diabetes mellitus (75.00% vs. 28.57%, P<0.05). The increase of creatine kinase[(393.23±4.81)U/L vs. (512.57±6.35)U/L,t=91.60, P<0.001] and lactate [(2.41±1.12)mmol/L vs. (10.83±2.34)mmol/L,t=20.49, P<0.001] as well as a decrease of the antithrombin III parameter[(62.85±5.20)%vs. (47.72±3.98)%,t=11.58, P<0.001] also proved to be a significant factor for a fatal prognosis. Conclusion Fournier's gangrene is known to have a high mortality. It is important that discovering and controlling predisposing or complication to decrease the mortality.