中华临床医师杂志(电子版)
中華臨床醫師雜誌(電子版)
중화림상의사잡지(전자판)
Chinese Journal of Clinicians (Electronic Edition)
2015年
20期
3696-3699
,共4页
李敏%吴俊华%吴晓惠%余文景%沙湖%梁翼
李敏%吳俊華%吳曉惠%餘文景%沙湖%樑翼
리민%오준화%오효혜%여문경%사호%량익
血管内皮生长因子%缺氧诱导因子1,α亚基%骨关节炎,膝%骨髓水肿
血管內皮生長因子%缺氧誘導因子1,α亞基%骨關節炎,膝%骨髓水腫
혈관내피생장인자%결양유도인자1,α아기%골관절염,슬%골수수종
Vascular endothelial growth factor%Hypoxia-inducible factor 1,alpha subunit%Osteoarthritis,knee%Bone marrow edema
目的:探讨血清血管内皮因子(VEGF)、缺氧诱导因子1α(HIF-1α)与伴有骨髓水肿的膝骨关节炎的相关性。方法收集我院绝经后女性膝骨关节炎患者50例,根据MRI表现分为骨髓水肿组(25例)和非骨髓水肿组(25例),分别收集其临床症状,WOMAC评分,并同期检测其血清VEGF、HIF-1α水平,采用方差分析比较两组之间的差异以及Spearman相关分析探讨其检测指标水平与骨髓水肿发生程度及其临床指标的相关性。结果(1)KOA 患者血清 VEGF、HIF-1α表达水平均呈正相关(r=0.976,P=0.000);(2)与非骨髓水肿组比较,骨髓水肿组血清HIF-1α、VEGF水平更高(F=6.253,P=0.016;F=7.218,P=0.010),夜间痛更明显(F=45.332,P=0.000);(3)骨髓水肿组内,骨髓水肿的容积积分、程度积分分别与血清 HIF-1α(r=0.597,P=0.002;r=0.475, P=0.017)、VEGF(r=0.582,P=0.002;r=0.486,P=0.014),夜间痛VAS评分(r=0.456,P=0.022;r=0.732,P=0.000)呈正相关。结论膝骨关节炎伴骨髓水肿时夜间痛明显,血清 HIF-1α、VEGF高表达。
目的:探討血清血管內皮因子(VEGF)、缺氧誘導因子1α(HIF-1α)與伴有骨髓水腫的膝骨關節炎的相關性。方法收集我院絕經後女性膝骨關節炎患者50例,根據MRI錶現分為骨髓水腫組(25例)和非骨髓水腫組(25例),分彆收集其臨床癥狀,WOMAC評分,併同期檢測其血清VEGF、HIF-1α水平,採用方差分析比較兩組之間的差異以及Spearman相關分析探討其檢測指標水平與骨髓水腫髮生程度及其臨床指標的相關性。結果(1)KOA 患者血清 VEGF、HIF-1α錶達水平均呈正相關(r=0.976,P=0.000);(2)與非骨髓水腫組比較,骨髓水腫組血清HIF-1α、VEGF水平更高(F=6.253,P=0.016;F=7.218,P=0.010),夜間痛更明顯(F=45.332,P=0.000);(3)骨髓水腫組內,骨髓水腫的容積積分、程度積分分彆與血清 HIF-1α(r=0.597,P=0.002;r=0.475, P=0.017)、VEGF(r=0.582,P=0.002;r=0.486,P=0.014),夜間痛VAS評分(r=0.456,P=0.022;r=0.732,P=0.000)呈正相關。結論膝骨關節炎伴骨髓水腫時夜間痛明顯,血清 HIF-1α、VEGF高錶達。
목적:탐토혈청혈관내피인자(VEGF)、결양유도인자1α(HIF-1α)여반유골수수종적슬골관절염적상관성。방법수집아원절경후녀성슬골관절염환자50례,근거MRI표현분위골수수종조(25례)화비골수수종조(25례),분별수집기림상증상,WOMAC평분,병동기검측기혈청VEGF、HIF-1α수평,채용방차분석비교량조지간적차이이급Spearman상관분석탐토기검측지표수평여골수수종발생정도급기림상지표적상관성。결과(1)KOA 환자혈청 VEGF、HIF-1α표체수평균정정상관(r=0.976,P=0.000);(2)여비골수수종조비교,골수수종조혈청HIF-1α、VEGF수평경고(F=6.253,P=0.016;F=7.218,P=0.010),야간통경명현(F=45.332,P=0.000);(3)골수수종조내,골수수종적용적적분、정도적분분별여혈청 HIF-1α(r=0.597,P=0.002;r=0.475, P=0.017)、VEGF(r=0.582,P=0.002;r=0.486,P=0.014),야간통VAS평분(r=0.456,P=0.022;r=0.732,P=0.000)정정상관。결론슬골관절염반골수수종시야간통명현,혈청 HIF-1α、VEGF고표체。
Objective To investigate the correlation of the serum and synovial fluid vascular endothelial growth factor (VEGF), hypoxia-inducible factor-1α (HIF-1α) and bone marrow edema associated with osteoarthritis of the knee (KOA). Methods The clinical data of 50 KOA of postmenopausal women, according to MRI, bone marrow edema group (25 cases) and bone marrow edema group (25 cases), were collected. The clinical symptoms, WOMAC score, and the serum VEGF, HIF-1αlevels were compared using ANOVA analysis and Spearman correlation analysis. Results (1)The serum VEGF, HIF-1α in osteoarthritis was positively correlated (r=0.976, P=0.000); (2)the serum HIF-1α(F=6.253, P=0.016), VEGF (F=7.218, P=0.010) levels and hypnalgia (F=45.332, P=0.000) of osteoarthritis with bone marrow edema group was significantly higher than that of the osteoarthritis without bone marrow edema group;(3)the serum HIF-1α, VEGF levels and hypnalgia were associated with osteoarthritis with bone marrow edema in volume (r=0.597, P=0.002; r=0.582, P=0.002; r=0.456, P=0.022) and degree (r=0.475, P=0.017;r=0.486, P=0.014;r=0.732, P=0.000) of integration. Conclusion The pain of the knee joint was obvious in the night with the bone marrow edema, and the HIF-1α, VEGF were high expression.