中华临床医师杂志（电子版）
中華臨床醫師雜誌（電子版）
중화림상의사잡지（전자판）
Chinese Journal of Clinicians (Electronic Edition)
2015年
20期
3680-3685
,共6页
受体,趋化因子%受体,表皮生长因子%转化生长因子%食管鳞状细胞癌%微血管密度
受體,趨化因子%受體,錶皮生長因子%轉化生長因子%食管鱗狀細胞癌%微血管密度
수체,추화인자%수체,표피생장인자%전화생장인자%식관린상세포암%미혈관밀도
Receptors,chemokine%Receptor,epidermal growth factor%Transforming growth factors%Esophageal squamous cell carcinoma%Microvascular density
目的：观察食管鳞状细胞癌中CXCR4、EGFR、TGFβ1、MVD的表达与临床病理特征的关系及预后意义。方法用免疫组化的方法，检测74例食管鳞状细胞癌及50例癌旁正常组织中CXCR4、EGFR、TGFβ1、MVD的表达情况，并结合病历资料分析研究其临床病理特征之间的关系。结果 CXCR4、EGFR、TGFβ1、MVD均在食管鳞状细胞癌组织中有较高的表达，在癌旁正常组织表达较低，二者差异有统计学意义（P＜0.01）。CXCR4、EGFR、MVD 的表达与食管鳞状细胞癌的淋巴结转移和TNM分期有相关性（P＜0.05），TGFβ1表达则不相关。CXCR4、EGFR、TGFβ1、MVD表达均与食管鳞状细胞癌患者的性别、年龄、肿瘤发生不同部位、肿瘤大小长度、细胞分化程度、吸烟嗜好、饮酒嗜好不相关。CXCR4分别与 EGFR、TGFβ1、MVD 在食管鳞状细胞癌中的表达具有正相关性（P＜0.05）。结论 CXCR4、EGFR、TGFβ1、MVD在食管鳞状细胞癌组织中均高表达，且CXCR4、EGFR、MVD与淋巴结转移和TNM分期有相关性，提示其与食管癌细胞的增殖、凋亡、浸润、转移等生物学行为密切相关。CXCR4、EGFR、TGFβ1、MVD的联合检测，对于食管鳞状细胞癌的早期诊断、预后判断、治疗选择都具有重要的意义。
目的：觀察食管鱗狀細胞癌中CXCR4、EGFR、TGFβ1、MVD的錶達與臨床病理特徵的關繫及預後意義。方法用免疫組化的方法，檢測74例食管鱗狀細胞癌及50例癌徬正常組織中CXCR4、EGFR、TGFβ1、MVD的錶達情況，併結閤病歷資料分析研究其臨床病理特徵之間的關繫。結果 CXCR4、EGFR、TGFβ1、MVD均在食管鱗狀細胞癌組織中有較高的錶達，在癌徬正常組織錶達較低，二者差異有統計學意義（P＜0.01）。CXCR4、EGFR、MVD 的錶達與食管鱗狀細胞癌的淋巴結轉移和TNM分期有相關性（P＜0.05），TGFβ1錶達則不相關。CXCR4、EGFR、TGFβ1、MVD錶達均與食管鱗狀細胞癌患者的性彆、年齡、腫瘤髮生不同部位、腫瘤大小長度、細胞分化程度、吸煙嗜好、飲酒嗜好不相關。CXCR4分彆與 EGFR、TGFβ1、MVD 在食管鱗狀細胞癌中的錶達具有正相關性（P＜0.05）。結論 CXCR4、EGFR、TGFβ1、MVD在食管鱗狀細胞癌組織中均高錶達，且CXCR4、EGFR、MVD與淋巴結轉移和TNM分期有相關性，提示其與食管癌細胞的增殖、凋亡、浸潤、轉移等生物學行為密切相關。CXCR4、EGFR、TGFβ1、MVD的聯閤檢測，對于食管鱗狀細胞癌的早期診斷、預後判斷、治療選擇都具有重要的意義。
목적：관찰식관린상세포암중CXCR4、EGFR、TGFβ1、MVD적표체여림상병리특정적관계급예후의의。방법용면역조화적방법，검측74례식관린상세포암급50례암방정상조직중CXCR4、EGFR、TGFβ1、MVD적표체정황，병결합병력자료분석연구기림상병리특정지간적관계。결과 CXCR4、EGFR、TGFβ1、MVD균재식관린상세포암조직중유교고적표체，재암방정상조직표체교저，이자차이유통계학의의（P＜0.01）。CXCR4、EGFR、MVD 적표체여식관린상세포암적림파결전이화TNM분기유상관성（P＜0.05），TGFβ1표체칙불상관。CXCR4、EGFR、TGFβ1、MVD표체균여식관린상세포암환자적성별、년령、종류발생불동부위、종류대소장도、세포분화정도、흡연기호、음주기호불상관。CXCR4분별여 EGFR、TGFβ1、MVD 재식관린상세포암중적표체구유정상관성（P＜0.05）。결론 CXCR4、EGFR、TGFβ1、MVD재식관린상세포암조직중균고표체，차CXCR4、EGFR、MVD여림파결전이화TNM분기유상관성，제시기여식관암세포적증식、조망、침윤、전이등생물학행위밀절상관。CXCR4、EGFR、TGFβ1、MVD적연합검측，대우식관린상세포암적조기진단、예후판단、치료선택도구유중요적의의。
Objective To investigate the expression of CXCR4, EGFR, TGFβ1 and MVD in esophageal squamous cell carcinoma and explore the correlation between each other, and its relationship with clinical pathological features. Methods Collected 74 cases from patients with esophageal squamous cell carcinoma and 50 cases of normal tissue adjacent to carcinoma. The expression of CXCR4, EGFR, TGFβ1, MVD was checked on the protein level by immunohistochemical method. Combined with the medical record data analysis, the relationship between them and the clinical pathological features were analyzed. Results CXCR4, EGFR, TGFβ1, MVD had higher expression in esophageal squamous carcinoma tissues and lower expression in normal tissue adjacent to carcinoma. The difference was statistically significant (P<0.01). There were close relations between the expression of CXCR4, EGFR, MVD and lymph node metastasis of esophageal squamous carcinoma and correlated with TNM staging (P<0.05), but TGFβ1 was not. There were not relevant relations between the expression level and the patients’ different gender, age, smoking habit, drinking alcoho, grade of differentiation, tumor site, tumor size, length. CXCR4 respectively with EGFR, TGFβ1, MVD expression in esophageal squamous cell carcinoma had a positive correlation (P<0.05). Conclusion CXCR4, EGFR, TGFβ1, MVD were highly expressed in esophageal squamous carcinoma tissues, and CXCR4, EGFR, MVD has correlation with lymph node metastasis and TNM stages, which suggest that they are closely related to proliferation, apoptosis, invasion, metastasis and the other biological behavior of esophageal cancer cell. The expression of CXCR4, EGFR, TGFβ1 and MVD in esophageal squamous carcinoma tissues have a positive correlation. The joint detection of CXCR4, EGFR, TGFβ1 and MVD may have important significance in the early diagnosis, choice of treatment and prognosis judgment of esophageal squamous cell carcinomas.
