中国药物评价
中國藥物評價
중국약물평개
Chinese Journal of Drug Evaluation
2015年
5期
302-306
,共5页
刘丽清%李美艳%侯宁%王爱武
劉麗清%李美豔%侯寧%王愛武
류려청%리미염%후저%왕애무
复方丹参滴丸%冠心病心绞痛%阿司匹林%Meta分析
複方丹參滴汍%冠心病心絞痛%阿司匹林%Meta分析
복방단삼적환%관심병심교통%아사필림%Meta분석
Compound danshen dropping pill%Angina pectoris of coronary heart disease%Aspirin%Meta-analysis
目的：评价复方丹参滴丸联合阿司匹林治疗冠心病心绞痛的安全性和疗效。方法：检索1994～2015年期间CNKI、VIP、CBM、Wanfang、PubMed数据库，收集复方丹参滴丸联合阿司匹林治疗冠心病心绞痛的随机对照临床研究，筛选符合纳入标准的文献，并应用改良Jadad表进行评价。采用Cochrane协作网免费提供的RevMan 5.0专用软件进行Meta分析。结果：初始检索到文献共190篇，纳入符合标准27篇，Jadad表评价后得24篇，包含2275名患者，Meta分析结果显示，复方丹参滴丸联合阿司匹林治疗冠心病心绞痛较单用阿司匹林有明显优势。其中临床疗效：同质性检验χ2＝6.61， df＝18，P＝0.99；合并效应值估计Z＝10.46，P＜0.0001，OR合并＝4.84，95％CI[3.60，6.51]。血脂水平改善：低密度蛋白（LDL）同质性检验χ2＝425.77，df＝7，P＜0.00001，合并效应值估计Z＝2.71，P＝0.006，MD合并＝-0.77，95％CI [-1.32，-0.23]。结论：与单独服用阿司匹林相比，复方丹参滴丸联合阿司匹林治疗对临床疗效和血脂水平改善效果更好，不良反应少。
目的：評價複方丹參滴汍聯閤阿司匹林治療冠心病心絞痛的安全性和療效。方法：檢索1994～2015年期間CNKI、VIP、CBM、Wanfang、PubMed數據庫，收集複方丹參滴汍聯閤阿司匹林治療冠心病心絞痛的隨機對照臨床研究，篩選符閤納入標準的文獻，併應用改良Jadad錶進行評價。採用Cochrane協作網免費提供的RevMan 5.0專用軟件進行Meta分析。結果：初始檢索到文獻共190篇，納入符閤標準27篇，Jadad錶評價後得24篇，包含2275名患者，Meta分析結果顯示，複方丹參滴汍聯閤阿司匹林治療冠心病心絞痛較單用阿司匹林有明顯優勢。其中臨床療效：同質性檢驗χ2＝6.61， df＝18，P＝0.99；閤併效應值估計Z＝10.46，P＜0.0001，OR閤併＝4.84，95％CI[3.60，6.51]。血脂水平改善：低密度蛋白（LDL）同質性檢驗χ2＝425.77，df＝7，P＜0.00001，閤併效應值估計Z＝2.71，P＝0.006，MD閤併＝-0.77，95％CI [-1.32，-0.23]。結論：與單獨服用阿司匹林相比，複方丹參滴汍聯閤阿司匹林治療對臨床療效和血脂水平改善效果更好，不良反應少。
목적：평개복방단삼적환연합아사필림치료관심병심교통적안전성화료효。방법：검색1994～2015년기간CNKI、VIP、CBM、Wanfang、PubMed수거고，수집복방단삼적환연합아사필림치료관심병심교통적수궤대조림상연구，사선부합납입표준적문헌，병응용개량Jadad표진행평개。채용Cochrane협작망면비제공적RevMan 5.0전용연건진행Meta분석。결과：초시검색도문헌공190편，납입부합표준27편，Jadad표평개후득24편，포함2275명환자，Meta분석결과현시，복방단삼적환연합아사필림치료관심병심교통교단용아사필림유명현우세。기중림상료효：동질성검험χ2＝6.61， df＝18，P＝0.99；합병효응치고계Z＝10.46，P＜0.0001，OR합병＝4.84，95％CI[3.60，6.51]。혈지수평개선：저밀도단백（LDL）동질성검험χ2＝425.77，df＝7，P＜0.00001，합병효응치고계Z＝2.71，P＝0.006，MD합병＝-0.77，95％CI [-1.32，-0.23]。결론：여단독복용아사필림상비，복방단삼적환연합아사필림치료대림상료효화혈지수평개선효과경호，불량반응소。
Objective:To evaluate effectiveness and safety of compound danshen dripping pills with aspirin in treating angina pectoris of coronary heart disease.Methods:Retrieving CNKI,VIP,CBM,Wan Fang medicine database,PubMed database,collecting randomized controlled trials Meta-analysis of compound danshen dripping pills with aspirin in treating angina pectoris of coronary heart disease, screening standard literature and evaluating the application by modified Jadad table.Using the cochrane collaboration free RevMan 5.0 dedicated software for Meta-analysis.Results:Retrieving a total of 290 references and 27 included articles were in accordance with the accepting articles.The Jadad table evaluation after 24,included 2275 patients.Meta-analysis results show that the compound danshen dropping pill with aspirin therapy of coronary heart disease angina pectoris aspirin alone has obvious advantages.The clinical curative effect:the homogeneity test chi-square =6.61, df =18, P =0.99.Consolidation effect value estimate Z =10.46, P <0.0001, OR merge=4.84,95%CI [3.60,6.51].Lipid levels improve: low density protein ( LDL) homogeneity test chi-square=425.77,df=7, P<0.00001.Consolidation effect value estimate Z =2.71, P =0.006, MD merger =0.77, 95%CI [-1.32, -0.23 ] . Conclusion:Compared with aspirin alone, compound danshen dropping pill with aspirin therapy for clinical curative effect and blood lip-id levels improved effect is better, less adverse reaction.
