CAJ | 학술논문

目的：了解表皮葡萄球菌对莫匹罗星的耐药情况，并探讨其耐药菌株对临床常用抗菌药物的耐药特性。方法收集2012年到2014年分离的表皮葡萄球菌498株，对表皮葡萄球菌临床分离株进行菌种鉴定和药敏试验；用K－B法测定表皮葡萄球菌临床分离株对莫匹罗星的耐药性。结果498株表皮葡萄球菌中，39株对莫匹罗星耐药，耐药率为7．8％（39／498）。39株莫匹罗星耐药的表皮葡萄球菌均为耐甲氧西林表皮葡萄球菌（ MRSE）。39株耐莫匹罗星的MRSE对奎诺普丁／达福普汀、利奈唑胺、万古霉素和呋喃妥因均表现为敏感，对青霉素、克林霉素、红霉素、环丙沙星和磺胺甲唑／甲氧苄啶等耐药率较高（＞60％），对庆大霉素、利福平耐药率超过35％。结论莫匹罗星对表皮葡萄球菌表现出较好的体外抗菌活性，但对莫匹罗星耐药的表皮葡萄球菌已在临床分离株中出现，耐药性问题不容忽视。
목적：료해표피포도구균대막필라성적내약정황，병탐토기내약균주대림상상용항균약물적내약특성。방법수집2012년도2014년분리적표피포도구균498주，대표피포도구균림상분리주진행균충감정화약민시험；용K－B법측정표피포도구균림상분리주대막필라성적내약성。결과498주표피포도구균중，39주대막필라성내약，내약솔위7．8％（39／498）。39주막필라성내약적표피포도구균균위내갑양서림표피포도구균（ MRSE）。39주내막필라성적MRSE대규낙보정／체복보정、리내서알、만고매소화부남타인균표현위민감，대청매소、극림매소、홍매소、배병사성화광알갑서／갑양변정등내약솔교고（＞60％），대경대매소、리복평내약솔초과35％。결론막필라성대표피포도구균표현출교호적체외항균활성，단대막필라성내약적표피포도구균이재림상분리주중출현，내약성문제불용홀시。
Objective To investigate the resistance of Staphylococcus epidermidis isolates to mupirocin and its resistant characteristics to anti-bacterial agents used in clinical.Methods A total of 489 Staphyloco-ccus epidermidis isoliates were isolated from the various specimens of pa-tients in our Hospital.The identification and antimicrobial susceptibility testing of Staphylococcus epidermidis isolates were determined by Vitek-2 Compact full automated Microbiology Analyzer.The susceptibility of 489 Staphylococcus epidermidis isolates to mupirocin was determined by disc-diffusion method.Results Among 489 Staphylococcus epidermidis clini-cal isolates, 39 methicillin -resistant Staphylococcus epidermidis ( MRSE) were resistant to mupirocin.The prevalence of mupirocin resis-tance among Staphylococcus epidermidis clinical isolates was 7.8%(39/498).All mupirocin-resistant isolates were susceptible to quinu-pristin/dalfopristin, linezolid, vancomycin and nitrofurantoin. While more than 60%of mupirocin-resistant isolates were resistant to penici-llin, clindamycin, erythromycin and trimethoprim/sulfamethoxazole.The resistance rates of mupirocin -resistant isolates to gentamicin and rifapin were more than 35%. Conclusion Mupirocin is an effective agent against Staphylococcus epidermidis isolates in vitro.However, the mupiro-cin-resistant Staphylococcus epidermidis has appeared in clinical isolates which is of concern.