CAJ | 학술논문

目的：评价薄芝糖肽联合腹水浓缩回输对肝硬化合并自发性细菌性腹膜炎的临床疗效和安全性。方法入选56例肝硬化合并自发性细菌性腹膜炎患者，随机分为对照组28例和试验组28例，试验组进行薄芝糖肽4 mL，每天1次，联合腹水浓缩回输治疗；对照组进行腹水浓缩回输治疗，均连续治疗2周。观察2组患者治疗前后脂多糖结合蛋白、肿瘤坏死因子－α和降钙素原水平，肝功能，并观察疗效和并发症情况。结果治疗后，2组患者脂多糖结合蛋白、肿瘤坏死因子－α和降钙素原水平均明显降低（ P＜0．05），且试验组明显低于对照组（ P＜0．05）。治疗后，试验组与对照组谷丙转氨酶降低，白蛋白水平明显升高（P＜0．05），且试验组谷丙转氨酶明显低于对照组，而白蛋白水平明显高于对照组（ P ＜0．05）。试验组治疗总有效率为82．14％，高于对照组的53．57％（ P＜0．05）。试验组并发症发生率为7．14％，明显低于对照组的32．14％（ P＜0．05）。结论薄芝糖肽联合腹水浓缩回输可有效治疗肝硬化合并自发性细菌性腹膜炎，改善患者临床症状，提高治疗效果。
목적：평개박지당태연합복수농축회수대간경화합병자발성세균성복막염적림상료효화안전성。방법입선56례간경화합병자발성세균성복막염환자，수궤분위대조조28례화시험조28례，시험조진행박지당태4 mL，매천1차，연합복수농축회수치료；대조조진행복수농축회수치료，균련속치료2주。관찰2조환자치료전후지다당결합단백、종류배사인자－α화강개소원수평，간공능，병관찰료효화병발증정황。결과치료후，2조환자지다당결합단백、종류배사인자－α화강개소원수평균명현강저（ P＜0．05），차시험조명현저우대조조（ P＜0．05）。치료후，시험조여대조조곡병전안매강저，백단백수평명현승고（P＜0．05），차시험조곡병전안매명현저우대조조，이백단백수평명현고우대조조（ P ＜0．05）。시험조치료총유효솔위82．14％，고우대조조적53．57％（ P＜0．05）。시험조병발증발생솔위7．14％，명현저우대조조적32．14％（ P＜0．05）。결론박지당태연합복수농축회수가유효치료간경화합병자발성세균성복막염，개선환자림상증상，제고치료효과。
Objective To investigated the effect and safety of Bozi glyco-peptide joint ascites reinfusion in the treatment cirrhosis conbined with pontaneous bacterial peritonitis.Methods A total of 56 cases of cirrhotic patients with spontaneous bacterial peritonitis were selected and divided into two groups.The control group (28 cases) were treated with ascites reinfusion while experiment group ( 28 cases ) were treated with Bozhi glycopeptide 4 mL joint ascites reinfusion for two weeks.Lipopolysaccha-ride -binding protein, tumor necrosis factor -αand procalcitonin levels, liver function, complications were observed before and after treat-ment.Results Lipopolysaccharide -binding protein, tumor necrosis factor -αand procalcitonin levels of two groups patients all obviously re-duced ( P <0.05 ) , and those of experiment group were significantly lower than the control group ( P<0.05).Alanine aminotransferase levels of two groups obviously reduced with albumin levels increased ( P<0.05) , and alanine aminotransferase of the experiment group was significantly lower than that of control group, the albumin level was higher ( P <0.05 ) . Total effective rate of the experiment group ( 82.14%) were significantly higher than that of control group (53.57%) (P<0.05).The complication rate of the experiment group (7.14%) were significantly lower than that of control group (32.14%) (P<0.05).Conclusion Bozhi glycopeptide joint ascites reinfusion can effectively treat cirrhosis combined with spontaneous bacterial peritonitis and improve clinical symptoms that can not only improve treat-ment but also be safe.