CAJ | 학술논문

目的：评价多药联合治疗肺炎支原体、幽门螺旋杆菌感染致小儿过敏性紫癜的临床疗效与安全性。方法将71例过敏性紫癜患儿分为肺炎支原体阳性者38例（ A组）和幽门螺旋杆菌阳性者33例（ B组）。2组患者均给予激素、钙剂及抗过敏治疗。 A组患儿予以口服10 mg? kg－1阿奇霉素，qd，每周一、二、三服用，停药4 d，疗程3周；B组患儿予以口服15 mg? kg－1? d－1克拉霉素，qd＋50 kg? d－1阿莫西林，tid＋0．8 kg? d－1奥美拉唑，qd，疗程3周。比较2组患者的临床疗效、6个月内紫癜复发情况及不良反应发生率。结果 A组的总有效率为89．5％，B组的总有效率为87．9％（P＞0．05）。随访期间，A组复发9例，B组复发7例，2组6个月内复发风险比较差异无统计学意义（ P＞0．05）。 A组发生恶心呕吐2例，B组发生恶心呕吐1例，2组均未见其他不良反应（ P＞0．05）。结论根据病原菌学情况制定多药联合方案治疗小儿过敏性紫癜的临床疗效更为确切、安全，且复发率更低。
목적：평개다약연합치료폐염지원체、유문라선간균감염치소인과민성자전적림상료효여안전성。방법장71례과민성자전환인분위폐염지원체양성자38례（ A조）화유문라선간균양성자33례（ B조）。2조환자균급여격소、개제급항과민치료。 A조환인여이구복10 mg? kg－1아기매소，qd，매주일、이、삼복용，정약4 d，료정3주；B조환인여이구복15 mg? kg－1? d－1극랍매소，qd＋50 kg? d－1아막서림，tid＋0．8 kg? d－1오미랍서，qd，료정3주。비교2조환자적림상료효、6개월내자전복발정황급불량반응발생솔。결과 A조적총유효솔위89．5％，B조적총유효솔위87．9％（P＞0．05）。수방기간，A조복발9례，B조복발7례，2조6개월내복발풍험비교차이무통계학의의（ P＞0．05）。 A조발생악심구토2례，B조발생악심구토1례，2조균미견기타불량반응（ P＞0．05）。결론근거병원균학정황제정다약연합방안치료소인과민성자전적림상료효경위학절、안전，차복발솔경저。
Objective To evaluate the clinical efficacy and safety of multiple drug treatment of children with allergic purpura caused by Myco-plasma pneumonia or Helicobacter pylori.Methods Seventy-one chil-dren diagnosed of allergic purpura were divided into group A ( mycoplas-ma pneumonia positive, n=38) and group B ( Helicobacter pylori posi-tive, n=33).All of included 71 cases were administered anti-anaphy-laxis as the basic treatment modality.Patients in the group A were also treated with azithromycin 10 mg? kg -1 , qd po with 1-3 days a week for 3 weeks. Patients in the group B were given clarithromycin 15 mg? kg-1? d -1 , qd +amoxicillin 50 kg? d -1 , tid +omeprazole 0.8 kg? d-1 , qd po for 3 weeks.After treatment, the clinical efficacy, toxicity and recurrence rate for the next 6 months were evaluated between the two groups.Results The clinical efficacy were 89.5%and 87.9%in the group A and B, respectively, without statistical difference ( P>0.05) .Nine and seven cases were found recurrence in group A and B, with no significant difference between the two groups ( P >0.05 ) . There were 2 and 1 nausea and vomiting cases in the group A and B respectively without statistical difference ( P >0.05 ) .Conclusion It was effective and safe for multiple drug treatment of children with allergic purpura caused by Mycoplasma pneumonia or Helicobacter pylori.