中华临床医师杂志（电子版）
中華臨床醫師雜誌（電子版）
중화림상의사잡지（전자판）
Chinese Journal of Clinicians (Electronic Edition)
2015年
20期
3787-3790
,共4页
脓毒症%血液滤过%炎症介导素类
膿毒癥%血液濾過%炎癥介導素類
농독증%혈액려과%염증개도소류
Sepsis%Hemofiltration%Inflammation mediators
脓毒症是危重患者的主要死亡原因之一，其严重程度与病死率正相关。脓毒症患者体内会产生大量的炎症介质，导致组织器官损伤。高容量血液净化是血液净化衍生出的一种技术，可以改善危重脓毒症患者预后，近10年临床研究主要集中在增加治疗剂量给患者带来的益处和血液净化治疗的时机方面。本文拟对高容量血液滤过的定义以及其在脓毒症治疗中的剂量、理论基础、技术进展、治疗时机等方面进行综述。
膿毒癥是危重患者的主要死亡原因之一，其嚴重程度與病死率正相關。膿毒癥患者體內會產生大量的炎癥介質，導緻組織器官損傷。高容量血液淨化是血液淨化衍生齣的一種技術，可以改善危重膿毒癥患者預後，近10年臨床研究主要集中在增加治療劑量給患者帶來的益處和血液淨化治療的時機方麵。本文擬對高容量血液濾過的定義以及其在膿毒癥治療中的劑量、理論基礎、技術進展、治療時機等方麵進行綜述。
농독증시위중환자적주요사망원인지일，기엄중정도여병사솔정상관。농독증환자체내회산생대량적염증개질，도치조직기관손상。고용량혈액정화시혈액정화연생출적일충기술，가이개선위중농독증환자예후，근10년림상연구주요집중재증가치료제량급환자대래적익처화혈액정화치료적시궤방면。본문의대고용량혈액려과적정의이급기재농독증치료중적제량、이론기출、기술진전、치료시궤등방면진행종술。
Sepsis is leading cause of death in the intensive care unit (ICU), its mortality is positive correlation with its severity. If sepsis develops, the body responds by producing chemicals which cause massive inflammation in the whole body. Inflammation is how body tissues react to infection, irritation or other injury. This inflammation can cause individual organs to fail. High-volume hemofiltration (HVHF) is a blood purification technique which may improve outcomes in critically ill patients with sepsis. Clinical research over the last decade concentrated on the possible clinical benefit by administering increased dose, which intensity or dose in continuous renal replacement therapy (CRRT) is usually defined as the effluent rate divided by body weight. This article reviewed recent progress in definition, dose, theoretical basis, technical progress, treatment time in patients with sepsis.
