CAJ | 학술논문

目的探讨影响丙戊酸钠血药浓度明显波动的原因. 方法病例收集:2013年我院使用丙戊酸钠治疗癫痫的患者的血药浓度监测情况(共101例,高效液相色谱法);对病例基本数据进行统计与分析. 结果列表格体现患者基本信息(包括患者年龄、用药剂型、合并用药等情况)同丙戊酸钠血药浓度变化的关系. 分析讨论可能存在的影响因素,对比其他文献得出影响丙戊酸钠血药浓度监测结果的原因. 结论丙戊酸钠血药浓度波动大受多方面因素共同影响,个体差异大,使用丙戊酸钠治疗癫痫时,应监测血药浓度,根据血药浓度及时调整给药剂量,以提高临床疗效、降低不良反应.
목적 탐토영향병무산납혈약농도명현파동적원인. 방법 병례수집:2013년아원사용병무산납치료전간적환자적혈약농도감측정황(공101례,고효액상색보법);대병례기본수거진행통계여분석. 결과 렬표격체현환자기본신식(포괄환자년령、용약제형、합병용약등정황)동병무산납혈약농도변화적관계. 분석토론가능존재적영향인소,대비기타문헌득출영향병무산납혈약농도감측결과 적원인. 결론 병무산납혈약농도파동대수다방면인소공동영향,개체차이대,사용병무산납치료전간시,응감측혈약농도,근거혈약농도급시조정급약제량,이제고림상료효、강저불량반응.
OBJECTIVE To find the facts which affects the plasma concentration of valproate( VPA) .METH-ODS Collecting the VPA plasma concentrations of epileptics who treated with VPA in our hospital during 2013(101 patients enrolled, plasma concentration were detected by HPLC ) .The datas were statisticsed and analyzed.RE-SULTS Factors may effects VPA Plasma concentration included age,dosage forms,drug combination and so on.Get the facts which effects VPA plasma concentration most according to statistical and analysis the datas combine with conclusions of previous studies.CONCLUSION VPA plasma concentration is effected with various fact.Individual difference is obvious in epileptics who treated with VPA.For the best efficacy and minimal adverse effect,VPA dos-age should be adjusted based on its plasma concentration.