CAJ | 학술논문

目的：探讨细胞质胸苷激酶1（TK1）在肺癌患者血清中的阳性率及其与肺癌临床病理学特点及预后的关系。方法：检测75例肺癌患者血清TK1水平，同时选取56例健康体检者作为对照。比较分析血清TK1水平与肺癌临床病理学特点及预后的关系。结果：肺癌患者血清TK1的阳性率（33.3%）高于健康对照组（12.5%），差异具有统计学意义（P=0.006）。有远处转移的患者血清TK1阳性率（53.8%）明显高于无远处转移的患者（22.4%），差异具有统计学意义（P=0.006）。TNM分期为晚期的肺癌患者血清TK1阳性率（54.5%）高于TNM分期早期的患者（16.7%），差异具有统计学意义（P=0.001）。肺癌患者血清中TK1的阳性率与患者性别、是否吸烟、有无淋巴结转移及肺癌的病理类型无相关性。血清TK1阴性患者的2年生存率（78%）显著高于TK1阳性患者（28%），差异具有统计学意义（P<0.001）。结论：血清TK1与肺癌远处转移相关，是肺癌患者预后不佳的标志之一。
목적：탐토세포질흉감격매1（TK1）재폐암환자혈청중적양성솔급기여폐암림상병이학특점급예후적관계。방법：검측75례폐암환자혈청TK1수평，동시선취56례건강체검자작위대조。비교분석혈청TK1수평여폐암림상병이학특점급예후적관계。결과：폐암환자혈청TK1적양성솔（33.3%）고우건강대조조（12.5%），차이구유통계학의의（P=0.006）。유원처전이적환자혈청TK1양성솔（53.8%）명현고우무원처전이적환자（22.4%），차이구유통계학의의（P=0.006）。TNM분기위만기적폐암환자혈청TK1양성솔（54.5%）고우TNM분기조기적환자（16.7%），차이구유통계학의의（P=0.001）。폐암환자혈청중TK1적양성솔여환자성별、시부흡연、유무림파결전이급폐암적병리류형무상관성。혈청TK1음성환자적2년생존솔（78%）현저고우TK1양성환자（28%），차이구유통계학의의（P<0.001）。결론：혈청TK1여폐암원처전이상관，시폐암환자예후불가적표지지일。
Objective:This study investigated the positive detection rate of cytoplasm thymidine kinase 1 (TK1) in lung cancer patients and the relationship of TK1 with clinicopathological features and prognosis. Methods:Sensitive chemiluminescence dot-blot assay was used to detect serum TK1 levels in 73 lung cancer patients and 56 normal control subjects. Results:The positive detection rate of TK1 was elevated in the lung cancer patients compared with the controls (P=0.006). The positive detection rate of TK1 was also correlated with distant metastases, but not with other factors, such as smoking, sex, lymph node metastasis, and pathology types. The 2 year survival of the patients with negative TK1 detection was significantly longer than that of the patients positively detected with the marker (P<0.001). Conclusion:Serum TK1, a new tumor marker, has potential applications in the diagnosis and prognosis of lung cancer.