CAJ | 학술논문

表面增强拉曼散射( SERS)生物传感技术是以生物成分为敏感元件或探测对象，研究生物分子间相互作用的重要工具之一，被广泛应用于环境监测、食品安全、临床检验及疾病诊断等众多领域。本文总结了耦合增强SERS生物传感技术方面的进展及其在分析检测和癌症诊断方面的应用。主要包括基于耦合增强SERS 生物传感技术方法、高灵敏度的SERS传感芯片的制备及其应用和新型SERS技术研究癌细胞及组织。
표면증강랍만산사( SERS)생물전감기술시이생물성분위민감원건혹탐측대상，연구생물분자간상호작용적중요공구지일，피엄범응용우배경감측、식품안전、림상검험급질병진단등음다영역。본문총결료우합증강SERS생물전감기술방면적진전급기재분석검측화암증진단방면적응용。주요포괄기우우합증강SERS 생물전감기술방법、고령민도적SERS전감심편적제비급기응용화신형SERS기술연구암세포급조직。
Biomolecule-assisted surface-enhanced Raman scattering ( SERS ) sensing is a technique using biological molecules as sensitive components or detected objects, which is one of the most important tools in the studies of biological molecules. SERS biosensing is widely used in environmental monitoring, food-safety, clinical testing, disease diagnosis, and many other areas. This paper summarizes the progresses on the application of SERS technique in the fields of the analysis and diagnosis of cancer. The contents mainly consist of three parts:(1) SERS biosensing technology based the new coupling mechanisms, involving SPR-coupling, waveguide-coupling and LSPR-PSPR coenhancement; ( 2 ) preparation and application of highly sensitive SERS chips;and (3) new SERS technology for investigating cancer cells and bio tissues.