海峡药学
海峽藥學
해협약학
Strait Pharmaceutical Journal
2015年
10期
78-80
,共3页
鼠神经生长因子%急性脑出血%临床神经功能缺损程度评分%日常生活活动能力量表
鼠神經生長因子%急性腦齣血%臨床神經功能缺損程度評分%日常生活活動能力量錶
서신경생장인자%급성뇌출혈%림상신경공능결손정도평분%일상생활활동능역량표
Mouse nerve growth factor%Cerebral hemorrhage%Chinese scale of clinical neurologic deficit( CSCND)%Barthel index ( BI)
目的 评价鼠神经生长因子治疗急性出血性脑血管病疗效. 方法 选择发病48 h内的急性出血性脑血管病患者98例,分为鼠神经生长因子组49例及对照组49例. 对照组按急性脑出血常规治疗,治疗组在常规治疗的基础上,给予鼠神经生长因子治疗. 两组均于治疗前及治疗后第十四天、二十八天分别进行临床神经功能缺损程度评分( CSCND)及日常生活活动能力量表 barthel指数( BI)评定,并观察鼠神经生长因子治疗期间不良反应. 结果 与治疗前比较,鼠神经生长因子组与对照组在治疗后14d、28d的临床神经功能缺损程度评分及BI评分差异均有统计学意义(P<0.01、P<0.05),与对照组比较,鼠神经生长因子组治疗14d、28d的临床神经功能缺损程度评分及BI评分差异也具有统计学意义( P<0.05 ). 结论 加用鼠神经生长因子对改善急性出血性脑血管病患者的神经功能缺损和日常生活活动能力水平疗效更好,鼠神经生长因子是一种治疗急性出血性脑血管病安全有效的药物.
目的 評價鼠神經生長因子治療急性齣血性腦血管病療效. 方法 選擇髮病48 h內的急性齣血性腦血管病患者98例,分為鼠神經生長因子組49例及對照組49例. 對照組按急性腦齣血常規治療,治療組在常規治療的基礎上,給予鼠神經生長因子治療. 兩組均于治療前及治療後第十四天、二十八天分彆進行臨床神經功能缺損程度評分( CSCND)及日常生活活動能力量錶 barthel指數( BI)評定,併觀察鼠神經生長因子治療期間不良反應. 結果 與治療前比較,鼠神經生長因子組與對照組在治療後14d、28d的臨床神經功能缺損程度評分及BI評分差異均有統計學意義(P<0.01、P<0.05),與對照組比較,鼠神經生長因子組治療14d、28d的臨床神經功能缺損程度評分及BI評分差異也具有統計學意義( P<0.05 ). 結論 加用鼠神經生長因子對改善急性齣血性腦血管病患者的神經功能缺損和日常生活活動能力水平療效更好,鼠神經生長因子是一種治療急性齣血性腦血管病安全有效的藥物.
목적 평개서신경생장인자치료급성출혈성뇌혈관병료효. 방법 선택발병48 h내적급성출혈성뇌혈관병환자98례,분위서신경생장인자조49례급대조조49례. 대조조안급성뇌출혈상규치료,치료조재상규치료적기출상,급여서신경생장인자치료. 량조균우치료전급치료후제십사천、이십팔천분별진행림상신경공능결손정도평분( CSCND)급일상생활활동능역량표 barthel지수( BI)평정,병관찰서신경생장인자치료기간불량반응. 결과 여치료전비교,서신경생장인자조여대조조재치료후14d、28d적림상신경공능결손정도평분급BI평분차이균유통계학의의(P<0.01、P<0.05),여대조조비교,서신경생장인자조치료14d、28d적림상신경공능결손정도평분급BI평분차이야구유통계학의의( P<0.05 ). 결론 가용서신경생장인자대개선급성출혈성뇌혈관병환자적신경공능결손화일상생활활동능력수평료효경호,서신경생장인자시일충치료급성출혈성뇌혈관병안전유효적약물.
OBJECTIVE To study the efficiency of mouse nerve growth factor in the treatment of acute cerebral hemorrhage.METHODS 98patientswithacuteintracerebralhemorrhagewererandomlyassignedintotwogroups:49 patients in the treatment group were given mouse nerve growth factor besides routine treatment for 14 days,other 49 patients were treated routinely without mouse nerve growth factor as the control group.Chinese scale of clinical neurologic deficit ( CSCND) and activities of daily living scale barthel index( BI) in the two group were assessed at different time points before treatment and 14 days、28 days after treatment.The changes of adverse reaction associated with the mouse nerve growth factor treatment were also observed.RESULTS After 14-day、28-day treatment,the re-sult of CCS and BI of two groups improved,and there was significant difference between the therapy group and control group ( P<0.01 , P <0.05 ) .And there was no obvious adverse reaction of the mouse nerve growth factor treat-ment.CONCLUSION Mouse nerve growth factor is efficacious and safe in the treatment of acute intracerebral hemorrhage due to the improvement of neurological impairment and activities of daily living in the patients.
