海峡药学
海峽藥學
해협약학
Strait Pharmaceutical Journal
2015年
10期
44-46
,共3页
胶囊用明胶%元素%ICP-MS%不确定度
膠囊用明膠%元素%ICP-MS%不確定度
효낭용명효%원소%ICP-MS%불학정도
Gelatin For Capsules%Elements%ICP-MS%Uncertainty
目的 建立ICP-MS法同时测定胶囊用明胶中铬、铜、砷、镉、铅5种有害元素含量的方法 ,并评定该方法 的测量不确定度. 方法 用硝酸微波消解样品,ICP-MS同时检测胶囊用明胶中5种有害元素的含量.并通过数学模型,计算方法 的不确定度.结果 5种元素的方法 检出限分别为0.075、0.141、0.039、0.013、0.099ng· mL -1,、线性关系良好(r>0.9995),回收率为95% ~105%,RSD小于10%,并提出了元素的测量不确定度评定程序. 结论 本方法 灵敏、准确、便捷,可同时测定胶囊用明胶中5种有害元素. 且ICP-MS的稳定性是测量准确性的关键.
目的 建立ICP-MS法同時測定膠囊用明膠中鉻、銅、砷、鎘、鉛5種有害元素含量的方法 ,併評定該方法 的測量不確定度. 方法 用硝痠微波消解樣品,ICP-MS同時檢測膠囊用明膠中5種有害元素的含量.併通過數學模型,計算方法 的不確定度.結果 5種元素的方法 檢齣限分彆為0.075、0.141、0.039、0.013、0.099ng· mL -1,、線性關繫良好(r>0.9995),迴收率為95% ~105%,RSD小于10%,併提齣瞭元素的測量不確定度評定程序. 結論 本方法 靈敏、準確、便捷,可同時測定膠囊用明膠中5種有害元素. 且ICP-MS的穩定性是測量準確性的關鍵.
목적 건립ICP-MS법동시측정효낭용명효중락、동、신、력、연5충유해원소함량적방법 ,병평정해방법 적측량불학정도. 방법 용초산미파소해양품,ICP-MS동시검측효낭용명효중5충유해원소적함량.병통과수학모형,계산방법 적불학정도.결과 5충원소적방법 검출한분별위0.075、0.141、0.039、0.013、0.099ng· mL -1,、선성관계량호(r>0.9995),회수솔위95% ~105%,RSD소우10%,병제출료원소적측량불학정도평정정서. 결론 본방법 령민、준학、편첩,가동시측정효낭용명효중5충유해원소. 차ICP-MS적은정성시측량준학성적관건.
OBJECTIVE To establish a method for the determination of hazard elements such as Cr,Cu,As,Cd and Pb in Gelatin for Capsules by inductively coupled plasma-mass spectrometry(ICP-MS).Evaluation of measure-ment uncertainty of the method.METHODS The samples were digested by nitric acid and microwave,and five haz-ard elements were determined by ICP-MS simultaneously.Calculation the uncertainty of the method by mathematical model.RESULTS The detection limit ranges of 5 hazard elements were 0.075,0.039,0.099ng· mL-1 ,the meth-od had good linear correlation( r>0.9995) ,and the average recoveries were in the range of 95%~105%with RSD less than 10%.Put forward the evaluation program of detection uncertainty.CONCLUSION This method is sensi-tive,accurate,convenient,and can be used to analyse the 5 elements in Gelatin For Capsules.The stability of the ICP-MS is the key to the measurement accuracy.
