中国免疫学杂志
中國免疫學雜誌
중국면역학잡지
Chinese Journal of Immunology
2015年
11期
1528-1531
,共4页
系膜增生性IgA肾小球肾病%人类白细胞抗原%基因分型%临床相关性
繫膜增生性IgA腎小毬腎病%人類白細胞抗原%基因分型%臨床相關性
계막증생성IgA신소구신병%인류백세포항원%기인분형%림상상관성
IgA mesangial proliferative glomerulonephritis%Human leukocyte antigen%Genotype%Clinical correlation
目的：探讨HLA-DRB1基因多态性与系膜增生性IgA肾病（ MsPGN）的临床相关性。方法：164例IgA MsPGN患者和164例健康受试者常规检查肾功能，采用PCR法测定HLA-DRB1基因分型，比较IgA MsPGN患者和健康受试者的肾功能及HLA-DRB1基因分型，并且分析IgA MsPGN患者HLA-DRB1基因分型与肾功能的关系。结果：（1）IgA MsPGN患者和健康受试者24 h尿蛋白、血清肌酐和血清尿素氮差异具有统计学意义（P＜0.01）；（2）在IgA MsPGN患者中，HLA-DRB1高频等位基因为DRB1*04、DRB1*07、DRB1*09、DRB1*11、DRB1*14和DRB1*15；（3）与健康受试者相比，DRB1*09和DRB1*11在IgA MsPGN患者的分布频率显著升高（P＜0.01或P＜0.05）；（4）DRB1*09和DRB1*11类型患者24 h蛋白尿、血清肌酐及血清尿素氮较HLA-DRB1其他基因类型的患者显著升高（ P＜0.01）。结论：HLA-DRB1基因多态性与系膜增生性IgA肾病相关，DRB1*09和DRB1*11类型可增加系膜增生性IgA肾病的风险，并且与患者肾小球肾炎严重程度有关。
目的：探討HLA-DRB1基因多態性與繫膜增生性IgA腎病（ MsPGN）的臨床相關性。方法：164例IgA MsPGN患者和164例健康受試者常規檢查腎功能，採用PCR法測定HLA-DRB1基因分型，比較IgA MsPGN患者和健康受試者的腎功能及HLA-DRB1基因分型，併且分析IgA MsPGN患者HLA-DRB1基因分型與腎功能的關繫。結果：（1）IgA MsPGN患者和健康受試者24 h尿蛋白、血清肌酐和血清尿素氮差異具有統計學意義（P＜0.01）；（2）在IgA MsPGN患者中，HLA-DRB1高頻等位基因為DRB1*04、DRB1*07、DRB1*09、DRB1*11、DRB1*14和DRB1*15；（3）與健康受試者相比，DRB1*09和DRB1*11在IgA MsPGN患者的分佈頻率顯著升高（P＜0.01或P＜0.05）；（4）DRB1*09和DRB1*11類型患者24 h蛋白尿、血清肌酐及血清尿素氮較HLA-DRB1其他基因類型的患者顯著升高（ P＜0.01）。結論：HLA-DRB1基因多態性與繫膜增生性IgA腎病相關，DRB1*09和DRB1*11類型可增加繫膜增生性IgA腎病的風險，併且與患者腎小毬腎炎嚴重程度有關。
목적：탐토HLA-DRB1기인다태성여계막증생성IgA신병（ MsPGN）적림상상관성。방법：164례IgA MsPGN환자화164례건강수시자상규검사신공능，채용PCR법측정HLA-DRB1기인분형，비교IgA MsPGN환자화건강수시자적신공능급HLA-DRB1기인분형，병차분석IgA MsPGN환자HLA-DRB1기인분형여신공능적관계。결과：（1）IgA MsPGN환자화건강수시자24 h뇨단백、혈청기항화혈청뇨소담차이구유통계학의의（P＜0.01）；（2）재IgA MsPGN환자중，HLA-DRB1고빈등위기인위DRB1*04、DRB1*07、DRB1*09、DRB1*11、DRB1*14화DRB1*15；（3）여건강수시자상비，DRB1*09화DRB1*11재IgA MsPGN환자적분포빈솔현저승고（P＜0.01혹P＜0.05）；（4）DRB1*09화DRB1*11류형환자24 h단백뇨、혈청기항급혈청뇨소담교HLA-DRB1기타기인류형적환자현저승고（ P＜0.01）。결론：HLA-DRB1기인다태성여계막증생성IgA신병상관，DRB1*09화DRB1*11류형가증가계막증생성IgA신병적풍험，병차여환자신소구신염엄중정도유관。
Objective:To explore the clinical correlation of HLA-DRB1 shared epitope with IgA mesangial proliferative glomer-ulonephritis( IgA MsPGN).Methods:The renal function were examined routinely,and HLA-DRB1 shared epitope were determined by PCR in a total of 164 patients with IgA MsPGN and 164 healthy subjects.The renal function and HLA-DRB1 shared epitope were compared in patients with IgA MsPGN and healthy subjects,and clinical correlation of HLA-DRB1 shared epitope and renal function were analyzed.Results:(1)24 h proteinuria,serum creatinine and serum urea nitrogen were significantly different in patients with IgA MsPGN and healthy subjects(P<0.01);(2)The high-frequency gene of HLA-DRB1 in patients with IgA MsPGN were DRB1*04, DRB1*07,DRB1*09,DRB1*11,DRB1*14 and DRB1*15;(3) The distribution frequency of DRB1*09 and DRB1*11 in patients with IgA MsPGN increased significantly(P<0.01 or P<0.05);(4)24 h proteinuria,serum creatinine and serum urea nitrogen in patients with IgA MsPGN with DRB1*09 and DRB1*11 were significantly different compared with those in patients with IgA MsPGN with other HLA-DRB1 shared epitope(P<0.01).Conclusion:HLA-DRB1 shared epitope is related to IgA MsPGN,DRB1*09 and DRB1*11 can increase the risk of IgA MsPGN,and related to the severity of glomerulonephritis.
