CAJ | 학술논문

目的：：观察不同剂量右美托咪定对肝癌根治术患者全麻苏醒期不良反应的影响。方法：60例择期行肝癌根治术的患者,随机分为右美托咪定1组( D1组)、右美托咪定2组( D2组)和对照组( C组)各20例,D1、D2组分别在手术结束前30 min微量泵持续静脉输注右美托咪定0.5μg/kg和1μg/kg,输注时间10 min,对照组持续输注同等容量0.9％氯化钠注射液。观察3组苏醒期循环情况、苏醒时间及拔管时间,同时观察躁动评分和镇静评分。结果：D1和D2组围拔管期各时点的血压、心率及术后躁动评分等均显著低于C组,而镇静评分显著高于C组(P<0.01),D1组苏醒时间及拔管时间与C组比较差异无统计学意义(P>0.05),而D2组苏醒时间及拔管时间均显著长于C组和D1组(P<0.01)。结论：手术结束前30 min静脉输注右美托咪定0.5μg/kg,可更好地维持肝癌根治术患者全麻苏醒期的血流动力学稳定,减少躁动,且不影响麻醉的苏醒时间。
목적：：관찰불동제량우미탁미정대간암근치술환자전마소성기불량반응적영향。방법：60례택기행간암근치술적환자,수궤분위우미탁미정1조( D1조)、우미탁미정2조( D2조)화대조조( C조)각20례,D1、D2조분별재수술결속전30 min미량빙지속정맥수주우미탁미정0.5μg/kg화1μg/kg,수주시간10 min,대조조지속수주동등용량0.9％록화납주사액。관찰3조소성기순배정황、소성시간급발관시간,동시관찰조동평분화진정평분。결과：D1화D2조위발관기각시점적혈압、심솔급술후조동평분등균현저저우C조,이진정평분현저고우C조(P<0.01),D1조소성시간급발관시간여C조비교차이무통계학의의(P>0.05),이D2조소성시간급발관시간균현저장우C조화D1조(P<0.01)。결론：수술결속전30 min정맥수주우미탁미정0.5μg/kg,가경호지유지간암근치술환자전마소성기적혈류동역학은정,감소조동,차불영향마취적소성시간。
Objective:To investigate the effects of the different doses of dexmedetomidine on the adverse reactions in the patients treated with resection of hepatocellular carcinoma during recovery period. Methods:Sixty patients scheduled by resection of hepatocellular carcinoma were randomly divided into the dexmedetomidine 1 and 2 group( D1 and D2 group) and control group. D1 and D2 group were treated with 0. 5μg/kg and 1μg/kg of dexmedetomidine by continuously intravenous injection for 10 min before 30 min of the end of operation,respectively,and the control group were treated with the same volume 0. 9% sodium chloride injection. The blood circulation,awakening and extubation time,and restlessness and sedation score in 3 groups during recovery period were observed. Results:The blood pressure and heart rate at each time-point during peri-extubation and postoperative restlessness score in D1 and D2 groups were significantly lower than those in control group(P<0. 01),while the sedation score in D1 and D2 groups was significantly higher than that in control group(P<0. 01). The differences of the awakening time and extubation time between D1 group and control group were not statistically significant(P>0. 05),while the awakening time in D2 group was significantly longer than that in control and D1 groups(P<0. 01). Conclusions:The intravenous injection with 0. 5μg/kg of dexmedetomidine at 30 min before the end of operation can keep the stabilization of hemodynamics during recovery period,reduce the restlessness,and does not affect the awakening time in the patients with resection of hepatocellular carcinoma.