CAJ | 학술논문

目的：研讨Graves’甲状腺功能亢进症（甲亢）患者运用甲巯咪唑与丙硫氧嘧啶治疗的临床作用。方法随机将我院门诊近两年时间诊疗的74例Graves’甲亢患者分组，观察组37例选择甲巯咪唑口服，对照组37例选择丙硫氧嘧啶治疗，针对两组的总体治疗情况作比较和评估。结果给药前，两组的TSH、FT3和FT4等指标值比较基本相当，不具统计学意义（P>0.05），给药后，观察组的TSH值相比对照组明显增高，而FT3和FT4值明显下降，有统计学意义（P<0.05）。两组给药期间均有不良症状出现，观察组发生率24.3%，与对照组的29.7%相比相当，不具统计学意义（P>0.05）。结论对Graves’甲亢患者实施甲巯咪唑治疗，疗效要较丙硫氧嘧啶理想，且用药安全，适合在临床推广。
목적：연토Graves’갑상선공능항진증（갑항）환자운용갑구미서여병류양밀정치료적림상작용。방법수궤장아원문진근량년시간진료적74례Graves’갑항환자분조，관찰조37례선택갑구미서구복，대조조37례선택병류양밀정치료，침대량조적총체치료정황작비교화평고。결과급약전，량조적TSH、FT3화FT4등지표치비교기본상당，불구통계학의의（P>0.05），급약후，관찰조적TSH치상비대조조명현증고，이FT3화FT4치명현하강，유통계학의의（P<0.05）。량조급약기간균유불량증상출현，관찰조발생솔24.3%，여대조조적29.7%상비상당，불구통계학의의（P>0.05）。결론대Graves’갑항환자실시갑구미서치료，료효요교병류양밀정이상，차용약안전，괄합재림상추엄。
Objective: Study of Graves’ hyperthyroidism (hyperthyroidism) patients using clinical effect of methimazole and propylthiouracil therapy. Methods: Randomly in our hospital in recent two years time of diagnosis and treatment of 74 cases of Graves’ hyperthyroidism patients were divided into observed group (37 cases with methimazole oral, control group of 37 cases with propylthiouracil treatment), for general treatment of two groups were compared and evaluated.Results: The FT3, FT4 and TSH in the two groups were similar before treatment, but the TSH value was significantly higher than that in the control group, while the FT3 and FT4 values were significantly decreased after treatment(P<0.05). Adverse symptoms occurred in the two groups, the observation group was 29.7%, compared with the control group 24.3%, not statistically significant (P>0.05). Conclusion: The implementation of methimazole treatment in patients with Graves’ hyperthyroidism effect to propylthiouracil ideal and it is safe to use, suitable for clinical application.