CAJ | 학술논문

外周血细胞减少是肝硬化门静脉高压性脾肿大患者常见且严重的并发症,并影响到预后,其原因有脾亢因素和非脾亢因素2种.我们应该正确认识这2种因素.脾亢因素较为常见,而非脾亢因素主要有病毒对骨髓的毒性作用、肝硬化、肝功能障碍、免疫缺陷、药物的毒性作用、营养障碍、血液循环中的血小板破坏和失血.病因治疗和肝移植是主要的治疗方式.目前改善外周血细胞的减少已成为一个热门的话题.本文就肝硬化门静脉高压症非脾亢因素导致外周血细胞减少的病因与治疗进行综述.
외주혈세포감소시간경화문정맥고압성비종대환자상견차엄중적병발증,병영향도예후,기원인유비항인소화비비항인소2충.아문응해정학인식저2충인소.비항인소교위상견,이비비항인소주요유병독대골수적독성작용、간경화、간공능장애、면역결함、약물적독성작용、영양장애、혈액순배중적혈소판파배화실혈.병인치료화간이식시주요적치료방식.목전개선외주혈세포적감소이성위일개열문적화제.본문취간경화문정맥고압증비비항인소도치외주혈세포감소적병인여치료진행종술.
The reduction of peripheral blood cells is a common and serious complication in hepatic cirrhosis portal hypertension patients with splenomegaly, and severely affects the prognosis.Its reasons include hypersplenism and non-hypersplenism factors.We should correctly understand these two factors.Hypersplenism factors is common, and non-hypersplenism factors, including the toxic effects of virus on the bone marrow, liver cirrhosis, hepatosis, immunodeficiency, the toxic effects of drugs, dystrophia, the destruction of platelets in blood circulation and hemorrhage.Etiological treatment and liver transplantation is the main treatment.Now, treatment of the reduction of peripheral blood cells has become an important topic.In this paper, the causes and treatments of peripheral blood cytopenias, which were caused by non-hypersplenism factors in the patients of liver cirrhosis and portal hypertension, were reviewed.