CAJ | 학술논문

白念珠菌是临床上最常见的条件致病真菌. 白念珠菌在感染宿主时会遭遇机械阻碍 (如上皮细胞),生物、化学和物理拮抗 (如胆汁、黏液、pH)及宿主免疫细胞 (如吞噬细胞)的杀伤. 白念珠菌生物化学、形态学的灵活性及逃逸宿主天然免疫的能力对其发挥致病性至关重要. 该文就白念珠菌感染宿主过程中涉及的分子机制做一综述,为进一步探索新的治疗药物提供参考.
백념주균시림상상최상견적조건치병진균. 백념주균재감염숙주시회조우궤계조애 (여상피세포),생물、화학화물리길항 (여담즙、점액、pH)급숙주면역세포 (여탄서세포)적살상. 백념주균생물화학、형태학적령활성급도일숙주천연면역적능력대기발휘치병성지관중요. 해문취백념주균감염숙주과정중섭급적분자궤제주일종술,위진일보탐색신적치료약물제공삼고.
Candida albicans is the most common human opportunistic fungal pathogen which have to cope with mechanical (e.g., epithelial) barriers,biochemical,chemical,and physical antagonists (e.g.,bile,mucus,pH),and the innate and adaptive immune system of thehost during its invading.Candida albicans's biochemistry,morphology flexibility and the ability to escape the host innate immunity plays crucial pathogenic roles.In this review we present an update on current understanding of the molecular mechanisms of infection of this pathogen in order to provide the reference to further explore new drugs.