广州化工
廣州化工
엄주화공
Guangzhou Chemical Industry
2015年
22期
24-26,35
,共4页
类黄酮%阿尔茨海默症%胆碱酯酶%抑制剂
類黃酮%阿爾茨海默癥%膽堿酯酶%抑製劑
류황동%아이자해묵증%담감지매%억제제
flavonoids%Alzheimer’s disease%cholinesterase%inhibitor
类黄酮是一类广泛分布于自然界的天然化合物,具有抗肿瘤、抗氧化、抗炎、血管舒张、神经元保护、保肝等多种生理活性,尤其是具有低毒的优势,使其在预防和治疗慢性疾病方面,如阿尔茨海默症( Alzheimer’s disease, AD)引起人们广泛关注。然而,类黄酮化合物与胆碱酯酶作用的研究报道还不是很多,因此,本文总结了近几年类黄酮化合物作为胆碱酯酶抑制剂的研究进展,期望为今后开发抗AD药物提供参考。
類黃酮是一類廣汎分佈于自然界的天然化閤物,具有抗腫瘤、抗氧化、抗炎、血管舒張、神經元保護、保肝等多種生理活性,尤其是具有低毒的優勢,使其在預防和治療慢性疾病方麵,如阿爾茨海默癥( Alzheimer’s disease, AD)引起人們廣汎關註。然而,類黃酮化閤物與膽堿酯酶作用的研究報道還不是很多,因此,本文總結瞭近幾年類黃酮化閤物作為膽堿酯酶抑製劑的研究進展,期望為今後開髮抗AD藥物提供參攷。
류황동시일류엄범분포우자연계적천연화합물,구유항종류、항양화、항염、혈관서장、신경원보호、보간등다충생리활성,우기시구유저독적우세,사기재예방화치료만성질병방면,여아이자해묵증( Alzheimer’s disease, AD)인기인문엄범관주。연이,류황동화합물여담감지매작용적연구보도환불시흔다,인차,본문총결료근궤년류황동화합물작위담감지매억제제적연구진전,기망위금후개발항AD약물제공삼고。
Flavonoids are a large class of compounds widely distributed in nature. Many of them expressed a wide range of biological activities such as anti-tumor, antioxidant, anti-inflammatory, vasodilator, neuron protection, hepatoprotective, and so on, espcially they show so low toxicity that they could be potential to treatment for chronic disease, such as Alzheimer’s disease ( AD) . In recent years, many research groups choose flavonoids to develop new drug for treatment of AD. Herein, current researches in flavonoids as cholinesterase inhibitors were systematically summarized, which can serve as a reference for designing new anti-AD drugs.
