国际医药卫生导报
國際醫藥衛生導報
국제의약위생도보
International Medicine and Health Guidance News
2015年
21期
3186-3188
,共3页
连续性血液净化%重症脓毒血症%抗凝%凝血功能
連續性血液淨化%重癥膿毒血癥%抗凝%凝血功能
련속성혈액정화%중증농독혈증%항응%응혈공능
Continuous blood purification%Severe sepsis%Anticoagulation%Coagulation function
目的 探讨不同抗凝方法对连续性血液净化(CBP)治疗重症脓毒血症的临床疗效.方法 以我院2013年3月至2015年3月收治的65例重症脓毒血症患者为研究对象,根据不同抗凝方法将其分为低分子肝素组与无肝素组,比较两组CBP治疗前、治疗后24 h凝血功能指标、血栓前体蛋白(TpP)、治疗后第28天存活率.结果 两组治疗后24hPT、TT、APTT、Fg、TpP较治疗前均明显下降,差异有统计学意义(P＜0.05),但治疗后两组间比较差异无统计学意义(P＞0.05).无肝素组治疗后第28天存活率为40.0％,与低分子肝素组的53.3％比较,差异无统计学意义(P＞0.05).结论 无肝素/低分子肝素连续性血液净化均能明显改善患者凝血功能,降低TpP水平,提高重症脓毒血症患者存活率.
目的 探討不同抗凝方法對連續性血液淨化(CBP)治療重癥膿毒血癥的臨床療效.方法 以我院2013年3月至2015年3月收治的65例重癥膿毒血癥患者為研究對象,根據不同抗凝方法將其分為低分子肝素組與無肝素組,比較兩組CBP治療前、治療後24 h凝血功能指標、血栓前體蛋白(TpP)、治療後第28天存活率.結果 兩組治療後24hPT、TT、APTT、Fg、TpP較治療前均明顯下降,差異有統計學意義(P＜0.05),但治療後兩組間比較差異無統計學意義(P＞0.05).無肝素組治療後第28天存活率為40.0％,與低分子肝素組的53.3％比較,差異無統計學意義(P＞0.05).結論 無肝素/低分子肝素連續性血液淨化均能明顯改善患者凝血功能,降低TpP水平,提高重癥膿毒血癥患者存活率.
목적 탐토불동항응방법대련속성혈액정화(CBP)치료중증농독혈증적림상료효.방법 이아원2013년3월지2015년3월수치적65례중증농독혈증환자위연구대상,근거불동항응방법장기분위저분자간소조여무간소조,비교량조CBP치료전、치료후24 h응혈공능지표、혈전전체단백(TpP)、치료후제28천존활솔.결과 량조치료후24hPT、TT、APTT、Fg、TpP교치료전균명현하강,차이유통계학의의(P＜0.05),단치료후량조간비교차이무통계학의의(P＞0.05).무간소조치료후제28천존활솔위40.0％,여저분자간소조적53.3％비교,차이무통계학의의(P＞0.05).결론 무간소/저분자간소련속성혈액정화균능명현개선환자응혈공능,강저TpP수평,제고중증농독혈증환자존활솔.
Objective To explore the clinical curative effect of continuous blood purification with different anticoagulation methods (CBP) in the treatment of severe sepsis.Methods 65 patients with severe sepsis admitted into our hospital from March, 2013 to March, 2015 were selected as study objects and were divided into a low molecular heparin (LMWH) group and a non-heparin group according to different anticoagulation methods.The coagulation indexes and thrombus precursor protein (TpP) before and 24 h after CBP and the survival rates 28 days after the treatment were compared between these two groups.Results PT, TT, APTT, Fg, and TpP were significantly lower 24 h after than before the treatment in both groups, with statistical differences (P ＜ 0.05).There were no statistical differences in PT, TT,APTT, Fg, and TpP between these two groups after the treatment (P ＞ 0.05).28 days after the treatment, the survival rate was 40.0％ in the non-heparin group and was 53.3％ in the LMWH group, with no statistical difference (P ＞ 0.05).Conclusions Continuous blood purification without heparin or with low molecular heparin for patients with severe sepsis can improve the patients' coagulation function, lower their TpP level, and increase their survival rate.
