CAJ | 학술논문

中心体异常扩增和多极纺锤体形成导致染色体分离缺陷,出现非整倍体细胞,促进染色体不稳定性形成,而染色体不稳定性是恶性肿瘤发生、发展的重要发病机制.中心粒复制相关因子(STIL)基因可与干细胞白血病/急性T淋巴细胞白血病(SCL/TAL1)基因形成融合基因,其编码蛋白参与中心粒形成及数目调控,活化CDK1/CyclinB1复合体、促进细胞进入有丝分裂期,通过Shh信号通路调控下游靶基因表达,与某些肿瘤的发生、发展密切有关.本文就STIL结构与功能,其与恶性肿瘤的相关性以及作用机制作一综述.
중심체이상확증화다겁방추체형성도치염색체분리결함,출현비정배체세포,촉진염색체불은정성형성,이염색체불은정성시악성종류발생、발전적중요발병궤제.중심립복제상관인자(STIL)기인가여간세포백혈병/급성T림파세포백혈병(SCL/TAL1)기인형성융합기인,기편마단백삼여중심립형성급수목조공,활화CDK1/CyclinB1복합체、촉진세포진입유사분렬기,통과Shh신호통로조공하유파기인표체,여모사종류적발생、발전밀절유관.본문취STIL결구여공능,기여악성종류적상관성이급작용궤제작일종술.
The hyperamplification in centrosomes give rise to a series of biochemical events including formation of multipolar spindle, abnormal segregation of chromosome and aneuploid, promoting the performance of chromosome instability, which is the main pathogenesis of multiple human malignancies.STIL participates in the formation of centrioles, activates CDK1/CyclinB1 complex and promotes mitotic entry.Moreover, it regulated expression of related downstream genes through Sonic Hedgehog signal pathway.Thus, STIL correlates with gastric and pancreatic carcinogenesis and progression.We aim to review the structure and function of STIL, association with malignancies and its potential mechanism.