中华流行病学杂志
中華流行病學雜誌
중화류행병학잡지
Chinese Journal of Epidemiology
2015年
11期
1288-1290
,共3页
极低出生体重儿%血清磷%骨碱性磷酸酶%25-羟基维生素D3
極低齣生體重兒%血清燐%骨堿性燐痠酶%25-羥基維生素D3
겁저출생체중인%혈청린%골감성린산매%25-간기유생소D3
Preterm infant with very low birth weight%Serum phosphorus%Bone alkaline phosphatase%25-Hydroxyvitamin D3
目的 调查分析极低出生体重早产儿血清磷(P)、骨碱性磷酸酶(BALP)、25-羟基维生素D[25-(OH)D3]水平动态变化,为临床早产儿代谢性骨病的早期预防提供指导.方法 选择入住烟台山医院新生儿科病房且符合入选标准的110例新生儿为研究对象,其中极低出生体重早产儿60例(病例组),足月产儿50例(对照组),分别于出生后1、4、12周空腹采取静脉血2 ml,测定血清P、BALP、25-(OH)D3水平,分析骨代谢指标的变化情况.结果 病例组25-(OH)D3水平增长速度低于对照组;两组血清P水平无明显变化.与对照组比较,病例组出生后1、4、12周血清BALP水平均显著性偏高;出生后第12周25-(OH)D3水平的差异有统计学意义,其中病例组异常率达26.7％,对照组异常率为0.结论 极低出生体重早产儿(病例组)出生后追赶性生长过程中血清BALP、25-(OH)D3水平与足月儿(对照组)有明显差异,提示该两项指标检测有助于极低出生体重儿代谢性骨病的早期发现及干预,其中以血清BALP指标敏感性较好.
目的 調查分析極低齣生體重早產兒血清燐(P)、骨堿性燐痠酶(BALP)、25-羥基維生素D[25-(OH)D3]水平動態變化,為臨床早產兒代謝性骨病的早期預防提供指導.方法 選擇入住煙檯山醫院新生兒科病房且符閤入選標準的110例新生兒為研究對象,其中極低齣生體重早產兒60例(病例組),足月產兒50例(對照組),分彆于齣生後1、4、12週空腹採取靜脈血2 ml,測定血清P、BALP、25-(OH)D3水平,分析骨代謝指標的變化情況.結果 病例組25-(OH)D3水平增長速度低于對照組;兩組血清P水平無明顯變化.與對照組比較,病例組齣生後1、4、12週血清BALP水平均顯著性偏高;齣生後第12週25-(OH)D3水平的差異有統計學意義,其中病例組異常率達26.7％,對照組異常率為0.結論 極低齣生體重早產兒(病例組)齣生後追趕性生長過程中血清BALP、25-(OH)D3水平與足月兒(對照組)有明顯差異,提示該兩項指標檢測有助于極低齣生體重兒代謝性骨病的早期髮現及榦預,其中以血清BALP指標敏感性較好.
목적 조사분석겁저출생체중조산인혈청린(P)、골감성린산매(BALP)、25-간기유생소D[25-(OH)D3]수평동태변화,위림상조산인대사성골병적조기예방제공지도.방법 선택입주연태산의원신생인과병방차부합입선표준적110례신생인위연구대상,기중겁저출생체중조산인60례(병례조),족월산인50례(대조조),분별우출생후1、4、12주공복채취정맥혈2 ml,측정혈청P、BALP、25-(OH)D3수평,분석골대사지표적변화정황.결과 병례조25-(OH)D3수평증장속도저우대조조;량조혈청P수평무명현변화.여대조조비교,병례조출생후1、4、12주혈청BALP수평균현저성편고;출생후제12주25-(OH)D3수평적차이유통계학의의,기중병례조이상솔체26.7％,대조조이상솔위0.결론 겁저출생체중조산인(병례조)출생후추간성생장과정중혈청BALP、25-(OH)D3수평여족월인(대조조)유명현차이,제시해량항지표검측유조우겁저출생체중인대사성골병적조기발현급간예,기중이혈청BALP지표민감성교호.
Objective To compare the levels of serum phosphorus,bone alkaline phosphatase and 25-hydroxyvitamin D3 in preterm infants with very low birth weight, and provide evidence for early screening, prevention of metabolic bone disease in preterm infants.Methods A total of 110 newborns who met the inclusion criteria were selected in pediatric ward in our hospital.The case group included 60 preterm infants with very low birth weight and control group included 50 full term infants.Fasting blood were taken from the subjects at week 1, 4, and 12 respectively, and ELISA was conducted to quantitatively detect the serum levels of phosphorus, bone alkaline phosphatase and 25-hydroxyvitamin D.Results The increase of serum 25-hydroxyvitamin D3 in case group was smaller than that in control group;the levels of serum phosphorus had no significant difference between two groups.In case group, the level of bone alkaline phosphatase increased at week 1,4, and 12, and the 25-hydroxyvitamin D3 level had significant difference at week 12 (P＜0.05).The abnormal rate of 25-hydroxyvitamin D3 level was 26.7％ for case group and 0％ for control group.Conclusion There were significant differences between case group and control group in levels of bone alkaline phosphatase and 25-hydroxyvitamin D3, suggesting that detecting the serum levels of bone alkaline phosphatase and 25-hydroxyvitamin D3 would facilitate the early diagnosis of metabolic bone disease in preterm infants.
