CAJ | 학술논문

目的提高对早期隆突性皮肤纤维肉瘤临床及组织病理的认识.方法回顾性分析中国医学科学院皮肤病医院2008-2014年诊断的14例早期隆突性皮肤纤维肉瘤的临床资料和组织病理特点.结果本组患者以年轻人多见,平均发病年龄为21岁,进展较慢,临床最初表现为界限清楚的萎缩性斑或硬化性斑块,其后逐渐出现结节性皮损.组织病理显示肿瘤细胞在真皮浅层数目较少,常平行于表皮,呈波浪状排列,而在真皮下部和皮下脂肪,肿瘤表现出经典型隆突性皮肤纤维肉瘤的改变.肿瘤细胞表达波形蛋白(vimentin)和CD34,但不表达S100和CD68.结论早期隆突性皮肤纤维肉瘤临床及组织学容易误诊多种良性疾病,重复活检及临床联系病理有助于本病的诊断.
목적 제고대조기륭돌성피부섬유육류림상급조직병리적인식.방법 회고성분석중국의학과학원피부병의원2008-2014년진단적14례조기륭돌성피부섬유육류적림상자료화조직병리특점.결과 본조환자이년경인다견,평균발병년령위21세,진전교만,림상최초표현위계한청초적위축성반혹경화성반괴,기후축점출현결절성피손.조직병리현시종류세포재진피천층수목교소,상평행우표피,정파랑상배렬,이재진피하부화피하지방,종류표현출경전형륭돌성피부섬유육류적개변.종류세포표체파형단백(vimentin)화CD34,단불표체S100화CD68.결론 조기륭돌성피부섬유육류림상급조직학용역오진다충량성질병,중복활검급림상련계병리유조우본병적진단.
Objective To improve understanding of the clinical and histopathological features of early stage dermatofibrosarcoma protuberans (DFSP).Methods The clinical data and histopathological findings of 14 cases of early stage DFSP diagnosed in Institute of Dermatology,Chinese Academy of Medical Sciences from 2008 to 2014 were retrospectively analyzed.Results The patients were mostly young people.The average age of onset was 21 years old.The progress was slow.The initial main manifestations were well-circumscribed atrophic erythema or sclerotic plaque,and subcutaneous nodules appeared gradually based on the erythema.Histopathology showed a small number of tumor ceils in the upper dermis,aligned parallel to the epidermis with wavy arrangement,while the tumor cells exhibited typical DFSP changes in the lower dermis and the subcutaneous fat.The tumor cells expressed vimentin and CD34,but not S100 and CD68.Conclusions Because the clinical and histological features are atypical,the early stage of DFSP is easily misdiagnosed as various benign diseases.Repeated biopsy and combining clinical features with pathological findings are helpful for diagnosis.