中华医学杂志
中華醫學雜誌
중화의학잡지
National Medical Journal of China
2015年
42期
3428-3431
,共4页
古丽孜巴尔·马木提%胡瑶%陈凤辉%黎怀星%程祖亨%玛依拉·吾甫尔
古麗孜巴爾·馬木提%鬍瑤%陳鳳輝%黎懷星%程祖亨%瑪依拉·吾甫爾
고려자파이·마목제%호요%진봉휘%려부성%정조형%마의랍·오보이
长寿%白细胞介素6%多态性,单核苷酸
長壽%白細胞介素6%多態性,單覈苷痠
장수%백세포개소6%다태성,단핵감산
Longevity%Interleukin-6%Polymorphism,single nucleotide
目的 初步探讨促炎症细胞因子基因变异是否与新疆维吾尔族人群自然长寿有关联.方法 将在1999至2012年纳入的240名来自新疆维吾尔自治区和田地区的维吾尔族长寿老人(≥90岁)和百岁老人作为长寿组,以及此期间同一地区与长寿组无任何血缘关系的92名在59~ 73岁之间自然死亡的维吾尔族人群作为对照组,检测肿瘤坏死因子α(TNF-α) (rs1800629)、白细胞介素6(IL-6)(rs1800796、rs10499563)、C反应蛋白(CRP)(rs2808630、rs1205)和IL-1β(rs1143623、rs16944)4个基因中7个单核苷酸多态性(SNP)位点.用logistic回归法评估病例-对照研究分析得出的各SNP与维吾尔族人群自然长寿之间的关联.结果 长寿组IL-6基因rs1800796位点C等位基因频率(0.298)低于对照组(0.435),差异有统计学意义(P =0.001).其余6个SNP在长寿组和对照组之间差异无统计学意义(均P >0.05).携带风险等位基因s1800796位点的CT单倍型与长寿之间有正相关关系(Padd=0.002,OR=1.983,95%CI:1.296 ~ 3.023),而其余单倍型与长寿没有显著关联.结论 IL-6基因的rs1800796位点多态可能与新疆维吾尔族自然长寿有关,IL-6基因rs1800796位点CT基因型与长寿有显著关系,C等位基因可能是长寿的不利因素.
目的 初步探討促炎癥細胞因子基因變異是否與新疆維吾爾族人群自然長壽有關聯.方法 將在1999至2012年納入的240名來自新疆維吾爾自治區和田地區的維吾爾族長壽老人(≥90歲)和百歲老人作為長壽組,以及此期間同一地區與長壽組無任何血緣關繫的92名在59~ 73歲之間自然死亡的維吾爾族人群作為對照組,檢測腫瘤壞死因子α(TNF-α) (rs1800629)、白細胞介素6(IL-6)(rs1800796、rs10499563)、C反應蛋白(CRP)(rs2808630、rs1205)和IL-1β(rs1143623、rs16944)4箇基因中7箇單覈苷痠多態性(SNP)位點.用logistic迴歸法評估病例-對照研究分析得齣的各SNP與維吾爾族人群自然長壽之間的關聯.結果 長壽組IL-6基因rs1800796位點C等位基因頻率(0.298)低于對照組(0.435),差異有統計學意義(P =0.001).其餘6箇SNP在長壽組和對照組之間差異無統計學意義(均P >0.05).攜帶風險等位基因s1800796位點的CT單倍型與長壽之間有正相關關繫(Padd=0.002,OR=1.983,95%CI:1.296 ~ 3.023),而其餘單倍型與長壽沒有顯著關聯.結論 IL-6基因的rs1800796位點多態可能與新疆維吾爾族自然長壽有關,IL-6基因rs1800796位點CT基因型與長壽有顯著關繫,C等位基因可能是長壽的不利因素.
목적 초보탐토촉염증세포인자기인변이시부여신강유오이족인군자연장수유관련.방법 장재1999지2012년납입적240명래자신강유오이자치구화전지구적유오이족장수노인(≥90세)화백세노인작위장수조,이급차기간동일지구여장수조무임하혈연관계적92명재59~ 73세지간자연사망적유오이족인군작위대조조,검측종류배사인자α(TNF-α) (rs1800629)、백세포개소6(IL-6)(rs1800796、rs10499563)、C반응단백(CRP)(rs2808630、rs1205)화IL-1β(rs1143623、rs16944)4개기인중7개단핵감산다태성(SNP)위점.용logistic회귀법평고병례-대조연구분석득출적각SNP여유오이족인군자연장수지간적관련.결과 장수조IL-6기인rs1800796위점C등위기인빈솔(0.298)저우대조조(0.435),차이유통계학의의(P =0.001).기여6개SNP재장수조화대조조지간차이무통계학의의(균P >0.05).휴대풍험등위기인s1800796위점적CT단배형여장수지간유정상관관계(Padd=0.002,OR=1.983,95%CI:1.296 ~ 3.023),이기여단배형여장수몰유현저관련.결론 IL-6기인적rs1800796위점다태가능여신강유오이족자연장수유관,IL-6기인rs1800796위점CT기인형여장수유현저관계,C등위기인가능시장수적불리인소.
Objective To investigate whether the variations of genes encoding pro-inflammatory cytokines is associated with longevity in Uyghurs in Xinjiang.Methods A total of 240 individuals aged ≥ 90 years from Xinjiang Uyghur Autonomous Region were enrolled between 1999 and 2012 as the longevity group,92 unrelated individuals from the same area who died naturally at the age of 59-73 in the same period were selected as the control group.Seven single nucleotide polymorphisms (SNPs) of 4 genes (tumor necrosis factor (TNF)-α (rs1800629),IL-6 (rs1800796,rs10499563),C-reactive protein (CRP) (rs2808630,rs1205) and IL-1 3 (rs1143623,rs16944)) were genotyped.Logistic regression was applied to assess the association between each individual SNP and longevity in case-control analyses.Results The distribution of C allele of rs1800796 in the longevity group (0.298) was lower than that in the control group (0.435) with statistical significance (P =0.001).The distributions of the other 6 genetic variations between the longevity group and the control group showed no statistically significant differences (all P > 0.05).CT genotype of rs1800796 was positively associated with longevity (Padd =0.002,OR =1.983,95% CI:1.296-3.023),while no significant association was noted between other genotypes and longevity.Conclusions SNP of rs1800796 of IL-6 gene may be significantly associated with longevity in Uyghurs in Xinjiang.CT genotype of rs1800796 is significantly associated with longevity.C allele of rs1800796 may be a negative factor for longevity.