肿瘤研究与临床
腫瘤研究與臨床
종류연구여림상
Cancer Research and Clinic
2015年
10期
655-657,663
,共4页
张京平%牛艳艳%苏丽萍%赵瑾
張京平%牛豔豔%囌麗萍%趙瑾
장경평%우염염%소려평%조근
复方橘皮竹茹胶囊%便秘%复方地芬诺酯%盐酸昂丹司琼
複方橘皮竹茹膠囊%便祕%複方地芬諾酯%鹽痠昂丹司瓊
복방귤피죽여효낭%편비%복방지분낙지%염산앙단사경
Compound orange peel bamboo shavings formula capsules%Constipation%Diphenoxylate%Ondansetron
目的 探讨复方橘皮竹茹胶囊对化学药物性便秘小鼠便秘的治疗作用.方法 以复方橘皮竹茹胶囊高、中、低三个剂量(3.2、1.6、0.8 g/kg)灌胃小鼠,观察药物对复方地芬诺酯、盐酸昂丹司琼致便秘小鼠排粪的影响.结果 对于复方地芬诺酯致便秘小鼠,中剂量复方橘皮竹茹胶囊缩短排粪潜伏期(P＜0.05),增加便秘第1、3小时排粪粒数(P＜0.05),中、高剂量增加4h粪粒质量(P＜0.05);对于盐酸昂丹司琼致便秘小鼠,中、高剂量复方橘皮竹茹胶囊缩短排粪潜伏期(P＜0.05),增加便秘第1、2、3小时小鼠排粪粒数(P＜0.05),低、中、高剂量增加4h粪粒质量(P＜0.05).结论 复方橘皮竹茹胶囊具有明显促进复方地芬诺酯、盐酸昂丹司琼致便秘小鼠的排粪作用.
目的 探討複方橘皮竹茹膠囊對化學藥物性便祕小鼠便祕的治療作用.方法 以複方橘皮竹茹膠囊高、中、低三箇劑量(3.2、1.6、0.8 g/kg)灌胃小鼠,觀察藥物對複方地芬諾酯、鹽痠昂丹司瓊緻便祕小鼠排糞的影響.結果 對于複方地芬諾酯緻便祕小鼠,中劑量複方橘皮竹茹膠囊縮短排糞潛伏期(P＜0.05),增加便祕第1、3小時排糞粒數(P＜0.05),中、高劑量增加4h糞粒質量(P＜0.05);對于鹽痠昂丹司瓊緻便祕小鼠,中、高劑量複方橘皮竹茹膠囊縮短排糞潛伏期(P＜0.05),增加便祕第1、2、3小時小鼠排糞粒數(P＜0.05),低、中、高劑量增加4h糞粒質量(P＜0.05).結論 複方橘皮竹茹膠囊具有明顯促進複方地芬諾酯、鹽痠昂丹司瓊緻便祕小鼠的排糞作用.
목적 탐토복방귤피죽여효낭대화학약물성편비소서편비적치료작용.방법 이복방귤피죽여효낭고、중、저삼개제량(3.2、1.6、0.8 g/kg)관위소서,관찰약물대복방지분낙지、염산앙단사경치편비소서배분적영향.결과 대우복방지분낙지치편비소서,중제량복방귤피죽여효낭축단배분잠복기(P＜0.05),증가편비제1、3소시배분립수(P＜0.05),중、고제량증가4h분립질량(P＜0.05);대우염산앙단사경치편비소서,중、고제량복방귤피죽여효낭축단배분잠복기(P＜0.05),증가편비제1、2、3소시소서배분립수(P＜0.05),저、중、고제량증가4h분립질량(P＜0.05).결론 복방귤피죽여효낭구유명현촉진복방지분낙지、염산앙단사경치편비소서적배분작용.
Objective To explore the effect of compound orange peel bamboo shavings formula capsules on constipation by examining on chemical constipation mice.Methods Constipation was induced by oral administration of diphenoxylate and ondansetron.Mice were fed with compound orange peel bamboo shavings formula capsule at the doses of 3.2, 1.6 and 0.8 g/kg, respectively.Results The middle dose and high dose of compound orange peel bamboo shavings formula capsule shortened the start time of defecation, and increased fecal pellets number and wet weight in the diphenoxylate-induced constipated mice or the ondansetron-induced constipated mice (P ＜ 0.05).Conclusion Compound orange peel bamboo shavings formula capsule produces a laxative activity against diphenoxylate-induced constipated mice or ondansetroninduced constipated mice.
