CAJ | 학술논문

目的探讨CA125对上皮性卵巢癌治疗及预后判断的价值.方法分析2003年1月至2009年12月收治的76例上皮性卵巢癌患者临床病理资料及治疗前后的CA125水平,并随访患者生存情况.结果治疗前CA125水平与上皮性卵巢癌的预后及手术减瘤的满意程度无关;术后3个疗程化疗后CA125水平正常与否的5年生存率分别为63.8％和25.0％,CA125水平正常患者的中位生存期长于异常患者(57、28个月,x2=19.951,P=0.000);治疗结束CA125水平≤10.0 U/ml和＞10.0U/ml患者的5年生存率分别为72.7％和42.8％,差异有统计学意义(x2=7.266,P=0.007).多因素分析显示,手术病理分期以及术后第3疗程后CA125是否降至正常是影响上皮性卵巢癌预后的独立因素(P＜0.05).结论血清CA125的水平与上皮性卵巢癌的预后密切相关,尤其是术后3个疗程化疗后CA125是否降至正常以及治疗结束CA125的水平,对预测上皮性卵巢癌患者的预后尤为重要.
목적 탐토CA125대상피성란소암치료급예후판단적개치.방법 분석2003년1월지2009년12월수치적76례상피성란소암환자림상병리자료급치료전후적CA125수평,병수방환자생존정황.결과 치료전CA125수평여상피성란소암적예후급수술감류적만의정도무관;술후3개료정화료후CA125수평정상여부적5년생존솔분별위63.8％화25.0％,CA125수평정상환자적중위생존기장우이상환자(57、28개월,x2=19.951,P=0.000);치료결속CA125수평≤10.0 U/ml화＞10.0U/ml환자적5년생존솔분별위72.7％화42.8％,차이유통계학의의(x2=7.266,P=0.007).다인소분석현시,수술병리분기이급술후제3료정후CA125시부강지정상시영향상피성란소암예후적독립인소(P＜0.05).결론 혈청CA125적수평여상피성란소암적예후밀절상관,우기시술후3개료정화료후CA125시부강지정상이급치료결속CA125적수평,대예측상피성란소암환자적예후우위중요.
Objective To explore the value of serum CA125 level to the prognosis of epithelial ovarian cancer.Methods The clinicopathologic data and serum CA125 level of 76 patients with epithelial ovarian cancer from Jan.2003 to Dec.2009 were analyzed retrospectively, and the outcomes of patients were followed up.Results No relationship was found between CA125 concentration before therapy with prognosis and cytoreductive condition for epithelial ovarian cancer.The normal or abnormal CA125 concentration after 3 courses of treatment meant different prognosis, with the 5-year survival rates of 63.8 ％ and 25.0 ％, and the median survival time of 57 months and 28 months, respectively (x2 =19.951, P =0.000).The 5-year survival rates of patients with CA125 concentration≤ 10.0 U/ml and＞10.0 U/ml after therapy were 72.7 ％ and 42.8 ％, respectively (x2 =7.266, P =0.007).According to multivariate Cox proportional-hazard model, two independent factors , operative pathological staging and CA125 concentration after 3 courses, were related significantly to the prognosis of epithelial ovarian cancer (P ＜ 0.05).Conclusion Serum CA125 level, especially after 3 courses and therapy, plays an important role in the prognosis of epithelial ovarian cancer.